The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin
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The Rac1 hypervariable region in targeting and signaling: a tail of many storiesThe Key Role of Calmodulin in KRAS-Driven AdenocarcinomasActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsStructural characterization of the interaction of human lactoferrin with calmodulinBoth the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulinDynamic multiprotein assemblies shape the spatial structure of cell signalingThe RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsA New View of Ras Isoforms in Cancers.GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.Survey of the year 2009: applications of isothermal titration calorimetry.Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.Modeling of RAS complexes supports roles in cancer for less studied partners.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Intrinsic protein disorder in oncogenic KRAS signaling.Regulation of K-Ras4B Membrane Binding by Calmodulin.Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding.A high pressure study of calmodulin-ligand interactions using small-angle X-ray and elastic incoherent neutron scattering.Probing conformational and functional substates of calmodulin by high pressure FTIR spectroscopy: influence of Ca2+ binding and the hypervariable region of K-Ras4B.
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P2860
The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The hypervariable region of K- ...... c interactions with calmodulin
@en
The hypervariable region of K- ...... interactions with calmodulin.
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type
label
The hypervariable region of K- ...... c interactions with calmodulin
@en
The hypervariable region of K- ...... interactions with calmodulin.
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prefLabel
The hypervariable region of K- ...... c interactions with calmodulin
@en
The hypervariable region of K- ...... interactions with calmodulin.
@nl
P2093
P2860
P356
P1433
P1476
The hypervariable region of K- ...... c interactions with calmodulin
@en
P2093
Lucy M Anderson
Richard J Calvert
Ryan P Nolet
Sherwin J Abraham
P2860
P304
P356
10.1021/BI900769J
P407
P50
P577
2009-08-01T00:00:00Z