Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.
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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated ActivationA method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligandPAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signalingRSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activationBAY61-3606 affects the viability of colon cancer cells in a genotype-directed mannerImpaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocksDevelopment and validation of a clinical trial patient stratification assay that interrogates 27 mutation sites in MAPK pathway genes.DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancerERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.KRAS and YAP1 converge to regulate EMT and tumor survivalThe crossroads between cancer stem cells and aging.Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expressionRegulation of RAS oncogenicity by acetylation.Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epitheliumRegulation of Ras proteins by reactive nitrogen species.Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progressionComparison of liver oncogenic potential among human RAS isoforms.HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RASNetwork analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras.Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells.The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.Chemoattractant-mediated Rap1 activation requires GPCR/G proteins.H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorises.Placental Ras Regulates Inflammation Associated with Maternal Obesity
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P2860
Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Non-redundancy within the RAS ...... ational disparities in cancer.
@en
Non-redundancy within the RAS ...... ational disparities in cancer.
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type
label
Non-redundancy within the RAS ...... ational disparities in cancer.
@en
Non-redundancy within the RAS ...... ational disparities in cancer.
@nl
prefLabel
Non-redundancy within the RAS ...... ational disparities in cancer.
@en
Non-redundancy within the RAS ...... ational disparities in cancer.
@nl
P2860
P1433
P1476
Non-redundancy within the RAS ...... ational disparities in cancer.
@en
P2093
Kevin M Haigis
P2860
P2888
P304
P356
10.1007/S10059-009-0143-7
P577
2009-09-30T00:00:00Z