Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.
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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humansReplicative and chronological aging in Saccharomyces cerevisiae.Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocationsThe small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiaeComparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.Calorie restriction and cancer prevention: metabolic and molecular mechanisms.Impact papers on aging in 2009.Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescenceLow protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.Combining magnetic sorting of mother cells and fluctuation tests to analyze genome instability during mitotic cell aging in Saccharomyces cerevisiae.Conserved role of medium acidification in chronological senescence of yeast and mammalian cellsChronological aging in Saccharomyces cerevisiae.Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae.Aging, nutrient signaling, hematopoietic senescence, and cancer.Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging.Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.Fasting and Caloric Restriction in Cancer Prevention and Treatment.Protective effects of short-term dietary restriction in surgical stress and chemotherapy.Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppressionStudying age-dependent genomic instability using the S. cerevisiae chronological lifespan model.Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevityAssessing chronological aging in Saccharomyces cerevisiae.Intermittent supplementation with rapamycin as a dietary restriction mimetic.Regenerative Medicine: Shedding Light on the Link between Aging and Cancer.High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells.Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.Overproduction of Sch9 leads to its aggregation and cell elongation in Saccharomyces cerevisiae.
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P2860
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@en
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@nl
type
label
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@en
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@nl
prefLabel
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@en
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@nl
P2093
P2860
P356
P1476
Oncogene homologue Sch9 promot ...... 1/Polzeta-dependent mechanism.
@en
P2093
Cristina Gattazzo
Federica Madia
Myron F Goodman
Phuong Pham
Valerie Yuan
Valter D Longo
P2860
P304
P356
10.1083/JCB.200906011
P407
P577
2009-08-17T00:00:00Z