The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages.
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Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activationNeutrophil apoptosis: relevance to the innate immune response and inflammatory disease.p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation.Tropheryma whipplei, the Whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway.Intracellular signal pathways: potential for therapies.SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signatureDistinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production.Inflammation and p53: A Tale of Two StressesA systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.Quantifying Ca2+ current and permeability in ATP-gated P2X7 receptors.p53 protects against LPS-induced lung endothelial barrier dysfunction.Chronic intestinal inflammation alters hippocampal neurogenesis.Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritisCyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4.p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-βCyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents.Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis.The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential.p53 and the Carcinogenicity of Chronic Inflammation.Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis.Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation.Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells.Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.The E3 ubiquitin ligase RNF144B is LPS-inducible in human, but not mouse, macrophages and promotes inducible IL-1β expression.Fas signaling in macrophages promotes chronicity in K/BxN serum-induced arthritis.On How Fas Apoptosis-Independent Pathways Drive T Cell Hyperproliferation and Lymphadenopathy in lpr Mice.Hypertonic Saline Primes Activation of the p53-p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines.MicroRNA-106b overexpression alleviates inflammation injury of cardiac endothelial cells by targeting BLNK via the NF-κB signaling pathway.p21(waf1/CIP1), a CDK inhibitor and a negative feedback system that controls macrophage activation.Systemic Inflammation as a Driver of Brain Injury: the Astrocyte as an Emerging Player.Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization
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The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The CDK domain of p21 is a sup ...... tion in activated macrophages.
@en
The CDK domain of p21 is a sup ...... tion in activated macrophages.
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type
label
The CDK domain of p21 is a sup ...... tion in activated macrophages.
@en
The CDK domain of p21 is a sup ...... tion in activated macrophages.
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prefLabel
The CDK domain of p21 is a sup ...... tion in activated macrophages.
@en
The CDK domain of p21 is a sup ...... tion in activated macrophages.
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P2093
P2860
P356
P1476
The CDK domain of p21 is a sup ...... tion in activated macrophages.
@en
P2093
Brittany Young
Damien S K Samways
Eric M Ruderman
Harris Perlman
John A Corbett
John C Scatizzi
Melissa Mavers
Terrance M Egan
P2860
P304
P356
10.1002/EJI.200838683
P407
P577
2009-03-01T00:00:00Z