Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. - Wikidata - awgldk - TriplyDB

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

http://www.wikidata.org/entity/Q37328447

about

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport Pendrin as a novel target for diuretic therapy Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation Aldosterone's rapid, nongenomic effects are mediated by striatin: a modulator of aldosterone's effect on estrogen action.NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).Role of epithelial sodium channels and their regulators in hypertension.Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.Purinergic inhibition of ENaC produces aldosterone escape The WNKs: atypical protein kinases with pleiotropic actions.Regression of albuminuria and hypertension and arrest of severe renal injury by a losartan-hydrochlorothiazide association in a model of very advanced nephropathy.Distal convoluted tubule γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.Conservation of Na+ vs. K+ by the rat cortical collecting duct.WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels.Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion.Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites Multigene kinase network, kidney transport, and salt in essential hypertension.Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathway Hypertension: the missing WNKs.Renal sodium transport in renin-deficient Dahl salt-sensitive rats.Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis.Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.

P2860

Q24633684-6E5BFD7D-F474-4BCF-9F1F-2CAFB20FA8B5 Q26741611-8302EB21-545B-43EE-B615-D933194DB31B Q26780484-DD538D0A-6305-412D-801B-926D96CF67CA Q26998714-3FE41F2F-125E-4B07-BB77-570C763AE8F1 Q28771509-A84ADEC1-45CD-4BA1-BBEB-4040553F025B Q28771740-E24403B4-BBA7-4994-8815-685EAE7F3985 Q30410186-F0B4BCF8-BBC1-4E8F-B74C-7D0D8213DA0F Q33590418-727820B8-9BB3-4F30-A6FB-60699ED65FED Q33660709-4F4F1AF7-02EA-40F7-9114-C8C5B8A39D90 Q34016466-DBD57513-A661-4CF5-8AEE-20CE7961A267 Q34060743-3DCA1843-298F-4E46-B6DF-E121EBD54F56 Q34155204-B1459372-2AE1-444F-8627-58D395451EF8 Q34251618-F04EA6DD-8B49-4D9E-AD62-B43C6CA42F37 Q34348908-2AF7E446-0CBB-4C32-B556-CB18199AFF58 Q34457049-7775C49B-F8D7-481F-B19C-A729B051AC5E Q34560188-DD0B7897-E43C-42D4-ADE4-EDC948B3428E Q34595011-3B77DF93-D0AD-412E-B972-65EAC9FF8F58 Q34629804-E05FEB08-1D78-4670-9CBF-C4DA5CFA51DA Q34695392-0506E950-1A09-4222-BB0B-23A88E7CE84F Q34787751-1A056FF4-3E7C-40C6-AE01-10F56A2013EB Q35086984-BD253CAD-9B10-427E-9B60-B1C1793CDB61 Q35159554-B2CA7105-A55B-4423-8101-776D6BA876A3 Q35210213-C4C0FCD9-43B0-4AB6-AAAC-AB2757ACEB1D Q35378323-9613528D-EB0A-41B9-866D-146CBE16F51D Q35622471-906736B4-688B-408A-B83E-6B005E591862 Q35952371-B6886EC8-1024-4858-BB7E-FD813CCFBAC0 Q35964473-DDD0D35E-6EBB-4412-9165-931033EAA6AE Q36106011-AB7C2156-1AEF-4083-BD53-BD05E47F35B8 Q36200260-A1AC55CB-2D78-460D-84C2-C31F12B8F7BB Q36323009-40961BC2-6420-4527-B85D-390A6CB06F67 Q36427915-704EE251-4CDF-4F7B-B3E1-8E8CB229268C Q36514922-B79CEA40-1EC8-416F-AD9E-8A1DF990F0A6 Q36527855-23740B68-0D99-4FAB-9C5D-DC02FA2D806F Q36862737-207E605F-A91B-4C07-A85B-73BA1989ADC5 Q36944645-A7E7B783-5602-43AF-AC6E-8606B6B24CB2 Q37025005-69180190-0EBA-4464-8348-C61E00B1A0DC Q37139457-1BAEE544-632F-46F7-B06B-0CDD56BD95E6 Q37401699-E6BCEC21-F14C-448A-B22E-ECF6C043F7BD Q37580301-CCB06D8F-5A16-4AFC-B41F-DAC22A0166B4 Q37604706-E9259AE6-9795-4602-870D-E1E5602BA775

P2860

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

http://www.wikidata.org/entity/Q37328447

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@en

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@nl

type

label

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@en

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@nl

prefLabel

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@en

Aldosterone mediates activatio ...... K1 and WNK4 signaling pathway.

@nl

P1433

Q37328447-4906C9BE-CB6A-4B00-A374-E7264D728351

P1476

Q37328447-F7DC2638-1CB5-47D1-8C52-6B65743FBDF9

P2093

Q37328447-12EE4E6E-D8FB-4FD0-B069-B934D73CF8D4

Q37328447-1D3F71B6-950E-4526-8693-3BF971A18FE6

Q37328447-5D4E25A2-A8B7-4835-B983-4EEC23BD7136

Q37328447-6042AE0B-354C-45A4-A202-308153E173BF

Q37328447-6233D9D7-3195-4A99-9024-76D0E70D3BFA

Q37328447-815D7C3C-332C-46B2-A758-841983E395F3

Q37328447-8F86A4B3-8483-42FC-B5BE-E42885688D3B

Q37328447-9D4523F8-F237-4B96-8BEA-7AD1E15C80D1

P2860

Q37328447-04B64A09-36B4-4032-9A5D-E9D450781F38

Q37328447-0F1A4A00-4F81-4B95-9619-8D5B4F7C26FE

Q37328447-1339E382-D4F2-4F9C-A820-9E53CFFD6E5F

Q37328447-195A5CE1-D6B6-4109-87D6-5ABF1F355522

Q37328447-19C72246-93AD-4745-A0BA-0C9CE5381BB3

Q37328447-1D0D7BEE-53B4-4D8F-A7E8-3B1AA1804B06

Q37328447-20C90A90-B0F4-4487-A289-7D4EB281C53D

Q37328447-279F0BFF-7834-4446-91C9-950DCA2911FD

Q37328447-2C5EE5B4-0ECF-401E-98A9-4E207160D6E1

Q37328447-37AAD011-E8DE-4E55-A5F0-F1288950A8AE

P304

Q37328447-BB6DAE93-82B6-4355-92D5-A88F157B4CB5

P31

Q37328447-8D9D39C3-A6E2-4C8C-BCC0-BDFE3090818E

P356

Q37328447-8425FD3B-6513-47C8-BA42-24B0F27CABD8

P407

Q37328447-84383413-541E-4D34-82A9-1EB1D068CB1A

P433

Q37328447-392B26A3-A787-4EF1-A187-3AB6AB18E4B1

P478

Q37328447-DF9D1723-0CAB-438E-8BA7-D777897529AC

P50

Q37328447-DD1FBEB6-2DA9-4F56-B661-9794F87BEF83

P577

Q37328447-B6F813FC-93FD-4390-B797-FACD234933FA

P698

Q37328447-558676CA-87F8-41AB-A9B4-7D16D9096CEF

P932

Q37328447-7A23775C-7396-4245-AD7B-A086854E465E

P356

P1433

Journal of Clinical Investigation

P1476

Aldosterone mediates activatio ...... GK1 and WNK4 signaling pathway

@en

P2093

Arohan R Subramanya

http://www.w3.org/2001/XMLSchema#string

Chao-Ling Yang

http://www.w3.org/2001/XMLSchema#string

David J Rozansky

http://www.w3.org/2001/XMLSchema#string

Larry L David

http://www.w3.org/2001/XMLSchema#string

Shaunessy Rogers

http://www.w3.org/2001/XMLSchema#string

Tonya Cornwall

http://www.w3.org/2001/XMLSchema#string

Xiaoman Zhu

http://www.w3.org/2001/XMLSchema#string

Yong-Feng Yang

http://www.w3.org/2001/XMLSchema#string

P2860

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

Characterization of the kinase activity of a WNK4 protein complex

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

P304

2601-2612

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI38323

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

119

http://www.w3.org/2001/XMLSchema#string

P50

David H. Ellison

P577

2009-08-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19690383

http://www.w3.org/2001/XMLSchema#string

P932

2735908

http://www.w3.org/2001/XMLSchema#string