Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.
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The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.Where now for anti-EGF receptor therapies in colorectal cancer?ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells.Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics.Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancerEffect of BRAF mutational status on expression profiles in conventional papillary thyroid carcinomasTNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survivalMuscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice.ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survivalERBB4 is over-expressed in human colon cancer and enhances cellular transformationRasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesisNeuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivoThe ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis.Genetic variants in ERBB4 is associated with chronic hepatitis B virus infectionArhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon.ADAM Proteases and Gastrointestinal Function.Alteration of WWOX in human cancer: a clinical view.ERBBs in the gastrointestinal tract: recent progress and new perspectives.Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.Potential of ErbB4 antibodies for cancer therapy.ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomasAn ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival.HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy.ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells.ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis.Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide.Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling.Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma.
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P2860
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 17 August 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@en
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@nl
type
label
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@en
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@nl
prefLabel
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@en
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@nl
P2093
P2860
P356
P1476
Tumor-specific apoptosis cause ...... n mouse intestinal epithelium.
@en
P2093
Christina Pannicia
Daekee Lee
Eunjung Lee
Hyunok Kim
Jonathan M Kurie
Kyoungmi Kim
Yanan Yang
P2860
P304
P356
10.1172/JCI36435
P407
P577
2009-08-17T00:00:00Z