Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.
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Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase IICyclin-dependent kinase 9-cyclin K functions in the replication stress responseFunctional association of Gdown1 with RNA polymerase II poised on human genesThe emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerComparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype SelectivityIkaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationFunctional characterization of a new member of the Cdk9 family in Aspergillus nidulans.Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinomaAFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.A role for CDK9-cyclin K in maintaining genome integrityMiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple OncogenesWogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites.Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation.The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translationATR signalling: more than meeting at the fork.SIRT2 directs the replication stress response through CDK9 deacetylation.Cyclin-dependent kinases: bridging their structure and function through computations.RNA polymerase II elongation control.Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.Cyclin-dependent kinase modulators and cancer therapy.Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function.The centrosome: a prospective entrant in cancer therapy.Overview of CDK9 as a target in cancer research.Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells.Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE.Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cellsFlavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.Growth inhibition of malignant glioblastoma by DING protein.Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse.CDK9: A key player in Cancer and Other Diseases.A Network of Regulations by Small Non-Coding RNAs: The P-TEFb Kinase in Development and Pathology.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.miR-206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9.UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate.
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Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role of the cyclin-dependent k ...... expression and human diseases.
@en
Role of the cyclin-dependent k ...... expression and human diseases.
@nl
type
label
Role of the cyclin-dependent k ...... expression and human diseases.
@en
Role of the cyclin-dependent k ...... expression and human diseases.
@nl
prefLabel
Role of the cyclin-dependent k ...... expression and human diseases.
@en
Role of the cyclin-dependent k ...... expression and human diseases.
@nl
P356
P1433
P1476
Role of the cyclin-dependent k ...... expression and human diseases.
@en
P2093
Gaetano Romano
P304
P356
10.4161/CC.7.23.7122
P577
2008-12-04T00:00:00Z