Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
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The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domainsIdentification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodiesDiverse functions of RNase L and implications in pathologyInhibition of Cellular 2'-5' Oligoadenylate Synthetase by the Herpes Simplex Virus Type 1 Us11 ProteinStructure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate ImmunityMonoclonal antibodies to 5'-triphospho-(2'-5')adenyladenosine oligonucleotidesInterferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase LConditions required for induction of interferon by rotaviruses and for their sensitivity to its actionRNase L dimerization in a mammalian two-hybrid system in response to 2',5'-oligoadenylates.Structural requirements of (2'-5') oligoadenylate for protein synthesis inhibition in human fibroblastsRibosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cellsImmunological evidence for the in vivo occurrence of (2'-5')adenylyladenosine oligonucleotides in eukaryotes and prokaryotesRegulation of the stability of poly(I)xpoly(C)-induced human fibroblast interferon mRNA: selective inactivation of interferon mRNA and lack of involvement of 2',5'-oligo(A) synthetase activation during the shutoff of interferon productionAbnormal behavior of interferon-induced enzymatic activities in an interferon-resistant cell line.Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase.Interferon-induced 2-5A synthetase activity in human peripheral blood mononuclear cells after immunization with influenza virus and rubella virus vaccinesDifferential antiviral effects of interferon in three murine cell lines.rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cellsMaintenance of protein synthesis in spite of mRNA breakdown in interferon-treated HeLa cells infected with reovirusGrowth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetaseElevated levels of (2'-5')oligoadenylic acid polymerase activity in growth-arrested human lymphoblastoid Namalva cellsComparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage.(2'-5')Oligoadenylate in rat liver: modulation after partial hepatectomyInduction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibitionCatalytic cleavage of an RNA target by 2-5A antisense and RNase L.Regulation of cell proliferation and differentiation by interferons.Ribonucleotide metabolism--fresh approaches to viral and cancer chemotherapy.The interferon renaissance: molecular aspects of induction and action.pppA2'p5A' blocks vesicular stomatitis virus replication in intact cells.Isolation and characterization of an interferon-resistant cell line deficient in the induction of (2'-5')oligoadenylate synthetase activityThe expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response.Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.Inhibition of protein synthesis by exogenous A2'p5'A2'p5'A (2-5 A core) and its bis-phosphoramidate analog in intact mouse lymphocytes, hepatocytes and bone marrow cells.Role of interferon-induced enzymes in the antiviral and antimitogenic effects of interferon.Protein kinase activity and the natural occurrence of 2-5A in interferon-treated EMC virus-infected L-cells.
P2860
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P2860
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 1979
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@en
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@nl
type
label
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@en
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@nl
prefLabel
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@en
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@nl
P2093
P2860
P356
P1476
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
@en
P2093
P2860
P304
P356
10.1073/PNAS.76.7.3261
P407
P577
1979-07-01T00:00:00Z