Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
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Synthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agentsAZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis.Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical functionAdrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacologyMolecular approaches to improving general anestheticsAdvancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.Anesthetic drug development: Novel drugs and new approaches.The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptorsClinical and molecular pharmacology of etomidate.Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in RatsDifferential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metaboliteActive emergence from propofol general anesthesia is induced by methylphenidate.Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical functionDistinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metaboliteγ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.The discovery of new anesthetics by targeting GABA(A) receptors.The role of etomidate as an anaesthetic induction agent for critically ill patients.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Pharmacologic Considerations for Pediatric Sedation and Anesthesia Outside the Operating Room: A Review for Anesthesia and Non-Anesthesia Providers.The future of anaesthetic pharmacology.Minimum infusion rate and adrenocortical function after continuous infusion of the novel etomidate analog ET-26-HCl in rats.Getting oil and water to mixSedative-hypnotic Binding to 11β-hydroxylase.Dimethoxy-etomidate: A Non-hypnotic Etomidate Analog that Potently Inhibits Steroidogenesis.The Role of GABA Receptor Agonists in Anesthesia and Sedation.The etomidate analog ET-26 HCl retains superior myocardial performance: Comparisons with etomidate in vivo and in vitro.Etomidate derivatives: Novel pharmaceutical agents in anesthesia.[Etomidate for intravenous induction of anaesthesia].Recent advances in intravenous anesthesia and anesthetics.Pretreatment with lidocaine reduces both incidence and severity of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
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P2860
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@en
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@nl
type
label
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@en
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@nl
prefLabel
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@en
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@nl
P2093
P2860
P1433
P1476
Methoxycarbonyl-etomidate: a n ...... ed adrenocortical suppression.
@en
P2093
Douglas E Raines
Elizabeth W Kelly
Hieu H Nguyen
Joseph F Cotten
Keith W Miller
S Shaukat Husain
Stuart A Forman
P2860
P304
P356
10.1097/ALN.0B013E3181AE63D1
P407
P577
2009-08-01T00:00:00Z