ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. - Wikidata - awgldk - TriplyDB

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

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Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.

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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

http://www.wikidata.org/entity/Q37336872

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 20 August 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@en

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

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label

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@en

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@nl

prefLabel

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@en

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@nl

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J.MCN.2016.08.004

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Molecular and Cellular Neuroscience

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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

@en

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Alice Goode

http://www.w3.org/2001/XMLSchema#string

Barry Shaw

http://www.w3.org/2001/XMLSchema#string

Mark S Searle

http://www.w3.org/2001/XMLSchema#string

Melanie Sultana

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P2860

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

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52-58

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scholarly article

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10.1016/J.MCN.2016.08.004

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76

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Robert Layfield

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2016-08-20T00:00:00Z

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27554286

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amyotrophic lateral sclerosis

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5062946

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