Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 - Wikidata - awgldk - TriplyDB

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

http://www.wikidata.org/entity/Q29616500

about

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression Cysteine-based regulation of the CUL3 adaptor protein Keap1 Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential Heme induces ubiquitination and degradation of the transcription factor Bach1 NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Antioxidant responses and cellular adjustments to oxidative stress Protein degradation and the stress response A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics Roles nrf2 plays in myeloid cells and related disorders Genetic and cellular characterization of Caenorhabditis elegans mutants abnormal in the regulation of many phase II enzymes Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response Structural analysis of the complex of Keap1 with a prothymosin α peptide Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Nrf2 mediates redox adaptations to exercise Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia Mechanistic studies of the Nrf2-Keap1 signaling pathway NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Stress-activated cap'n'collar transcription factors in aging and human disease CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis

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P2860

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

http://www.wikidata.org/entity/Q29616500

description

2006 nî lūn-bûn

@nan

2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Oxidative and electrophilic st ...... iquitination activity of Keap1

@ast

Oxidative and electrophilic st ...... iquitination activity of Keap1

@en

type

label

Oxidative and electrophilic st ...... iquitination activity of Keap1

@ast

Oxidative and electrophilic st ...... iquitination activity of Keap1

@en

prefLabel

Oxidative and electrophilic st ...... iquitination activity of Keap1

@ast

Oxidative and electrophilic st ...... iquitination activity of Keap1

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MCB.26.1.221-229.2006

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Molecular and Cellular Biology

P1476

Oxidative and electrophilic st ...... iquitination activity of Keap1

@en

P2093

Kit I Tong

http://www.w3.org/2001/XMLSchema#string

Koji Uchida

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Moon-Il Kang

http://www.w3.org/2001/XMLSchema#string

Takahiro Shibata

http://www.w3.org/2001/XMLSchema#string

Yoriko Watai

http://www.w3.org/2001/XMLSchema#string

P2860

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

The ubiquitin system

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221-229

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scholarly article

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1105621

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10.1128/MCB.26.1.221-229.2006

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1

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26

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Akira Kobayashi

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2006-01-01T00:00:00Z

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16354693

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protein ubiquitination

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1317630

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