Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer.
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Gene delivery polymer structure-function relationships elucidated via principal component analysis.Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cellsBiodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivoCancer research by means of tissue engineering--is there a rationale?A bioreducible linear poly(β-amino ester) for siRNA delivery.Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNAPolymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cellsCombinatorial optimization of PEG architecture and hydrophobic content improves ternary siRNA polyplex stability, pharmacokinetics, and potency in vivo.Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytesTherapeutic nanomedicine for brain cancer.(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(Bioengineered nanoparticles for siRNA delivery.Targeted Nanotechnology in Glioblastoma Multiforme.Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.Recent advances in characterization of nonviral vectors for delivery of nucleic acids: impact on their biological performance.RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies.Non-viral nucleic acid containing nanoparticles as cancer therapeuticsPolymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma.Continuous microfluidic assembly of biodegradable poly(beta-amino ester)/DNA nanoparticles for enhanced gene delivery.Suppression of VEGF by reversible-PEGylated histidylated polylysine in cancer therapy.Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases.Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survivalA Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection.Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy.Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.
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P2860
Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 September 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Subtle changes to polymer stru ...... elivery to human brain cancer.
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Subtle changes to polymer stru ...... elivery to human brain cancer.
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type
label
Subtle changes to polymer stru ...... elivery to human brain cancer.
@en
Subtle changes to polymer stru ...... elivery to human brain cancer.
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prefLabel
Subtle changes to polymer stru ...... elivery to human brain cancer.
@en
Subtle changes to polymer stru ...... elivery to human brain cancer.
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P2860
P356
P1476
Subtle changes to polymer stru ...... elivery to human brain cancer.
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P2093
Jordan J Green
Stephany Y Tzeng
P2860
P304
P356
10.1002/ADHM.201200257
P577
2012-09-26T00:00:00Z