The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures
about
Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties.A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles.Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cellsEffects of base polymer hydrophobicity and end-group modification on polymeric gene deliveryOrgan-on-a-chip platforms for studying drug delivery systems.Gene delivery nanoparticles specific for human microvasculature and macrovasculature.2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery.Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo.A bioreducible linear poly(β-amino ester) for siRNA delivery.Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cellsPolymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cellsSynthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.Targeted polymeric nanoparticles for cancer gene therapy.Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo.Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities.Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytesTransfection in the third dimension.Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer.Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery.Emerging in vitro models for safety screening of high-volume production nanomaterials under environmentally relevant exposure conditions.Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma.Nanotherapeutic systems for local treatment of brain tumors.Evaluation of polymeric gene delivery nanoparticles by nanoparticle tracking analysis and high-throughput flow cytometry.Effects of trehalose polycation end-group functionalization on plasmid DNA uptake and transfection.Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy.Nanoparticle Tracking Analysis for Determination of Hydrodynamic Diameter, Concentration, and Zeta-Potential of Polyplex Nanoparticles.A549 and MRC-5 cell aggregation in a microfluidic Lab-on-a-chip system.Studies of anticancer drug cytotoxicity based on long-term HepG2 spheroid culture in a microfluidic system.Optimized delivery of siRNA into 3D tumor spheroid cultures in situ.
P2860
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P2860
The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The relationship between termi ...... s and 3-D organotypic cultures
@ast
The relationship between termi ...... s and 3-D organotypic cultures
@en
type
label
The relationship between termi ...... s and 3-D organotypic cultures
@ast
The relationship between termi ...... s and 3-D organotypic cultures
@en
prefLabel
The relationship between termi ...... s and 3-D organotypic cultures
@ast
The relationship between termi ...... s and 3-D organotypic cultures
@en
P2093
P2860
P1433
P1476
The relationship between termi ...... s and 3-D organotypic cultures
@en
P2093
Andrew J Ewald
Joel C Sunshine
Jordan J Green
Nupura S Bhise
Ryan S Gray
P2860
P304
P356
10.1016/J.BIOMATERIALS.2010.07.023
P577
2010-07-31T00:00:00Z