Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.
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LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in miceEndocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouseAcromegaly pathogenesis and treatmentEnergy metabolism in the liverBioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?Tissue-Specific GHR Knockout Mice: Metabolic PhenotypesPrenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IGF-I in a sex-specific fashionLipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity.Biological effects of growth hormone on carbohydrate and lipid metabolism.Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropesMinireview: mechanisms of growth hormone-mediated gene regulation.A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation.Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein.Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse modelPreventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats.Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance.Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice.Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout miceAbrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependentContext-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma.Growth hormone and adipose tissue: beyond the adipocyte.Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-IGene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes.Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment.The intricate role of growth hormone in metabolism.Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult MiceRemoval of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.
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P2860
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@en
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@nl
type
label
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@en
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@nl
prefLabel
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@en
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@nl
P2093
P2860
P356
P1476
Liver-specific deletion of the ...... g in hepatic lipid metabolism.
@en
P2093
David Hwang
Derek Le Roith
Douglas J DiGirolamo
John J Kopchick
Mark A Sperling
Massimo Trucco
Pinchas Cohen
Ram K Menon
Thomas Clemens
P2860
P304
19937-19944
P356
10.1074/JBC.M109.014308
P407
P577
2009-05-21T00:00:00Z