Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
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Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infectionGene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collectionMitochondrial electron transport is the cellular target of the oncology drug elesclomolA universal TagModule collection for parallel genetic analysis of microorganisms.Compound prioritization methods increase rates of chemical probe discovery in model organisms.Modulation of morphogenesis in Candida albicans by various small molecules.Characterization of a lysophospholipid acyltransferase involved in membrane remodeling in Candida albicans.Branched-chain fatty acids promote Listeria monocytogenes intracellular infection and virulence.The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production.Target identification of small molecules based on chemical biology approaches.Genetic Approaches to Facilitate Antibacterial Drug Development.A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis.High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.Budding off: bringing functional genomics to Candida albicans.The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis.A survey of yeast genomic assays for drug and target discovery.Bugs, drugs and chemical genomics.Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels.Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance.1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii.1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.Unraveling the biology of a fungal meningitis pathogen using chemical genetics.Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans.Candida parapsilosis: an emerging pathogen developing its own identity.Chemogenomic profiling of the fungal pathogen Candida albicans.
P2860
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P2860
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chemical genetic profiling and ...... tty acids in Candida albicans.
@en
Chemical genetic profiling and ...... tty acids in Candida albicans.
@nl
type
label
Chemical genetic profiling and ...... tty acids in Candida albicans.
@en
Chemical genetic profiling and ...... tty acids in Candida albicans.
@nl
prefLabel
Chemical genetic profiling and ...... tty acids in Candida albicans.
@en
Chemical genetic profiling and ...... tty acids in Candida albicans.
@nl
P2093
P2860
P356
P1476
Chemical genetic profiling and ...... atty acids in Candida albicans
@en
P2093
Chanseok Oh
Charles E Martin
Jeffrey Becker
John Davison
Karynn Veillette
Minghui Yang
P2860
P304
19754-19764
P356
10.1074/JBC.M109.019877
P407
P50
P577
2009-06-01T00:00:00Z