SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
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SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathyDevelopment of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDG.Transgenic knockdown of cardiac sodium/glucose cotransporter 1 (SGLT1) attenuates PRKAG2 cardiomyopathy, whereas transgenic overexpression of cardiac SGLT1 causes pathologic hypertrophy and dysfunction in mice.Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice.Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium DesensitizationCardioprotective effect of ritonavir, an antiviral drug, in isoproterenol induced myocardial necrosis: a new therapeutic implicationRationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial.Localisation of AMPK γ subunits in cardiac and skeletal musclesJAK-STAT signaling and myocardial glucose metabolism.Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis.Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.Real-time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cellsEnergetics and metabolism in the failing heart: important but poorly understood.Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus.Mechanisms of subcellular remodeling in heart failure due to diabetes.SGLT inhibitors: a novel target for diabetes.Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus.Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus.Novel Sulfur Metabolites of Garlic Attenuate Cardiac Hypertrophy and Remodeling through Induction of Na+/K+-ATPase Expression.Synthesis and SAR of Benzisothiazole- and Indolizine-β-d-glucopyranoside Inhibitors of SGLT2.Glucose transporters: physiological and pathological roles.Diallyl disulfide ameliorates isoproterenol induced cardiac hypertrophy activating mitochondrial biogenesis via eNOS-Nrf2-Tfam pathway in ratsMetabolic Origins of Heart Failure.The effect and action mechanism of resveratrol on the vascular endothelial cell by high glucose treatment.Structural insights into genetic variants of Na(+)/glucose cotransporter SGLT1 causing glucose-galactose malabsorption: vSGLT as a model structure.Expression profiling and immunolocalization of Na+-D-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats.A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.Direct cardiovascular impact of SGLT2 inhibitors: mechanisms and effects.Cardiac effects of SGLT2 inhibitors: the sodium hypothesis.Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2.Nitric oxide synthase inhibition abrogates hydrogen sulfide-induced cardioprotection in mice.Dual inhibition of sodium–glucose linked cotransporters 1 and 2 exacerbates cardiac dysfunction following experimental myocardial infarction.NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1Myocyte [Na] Dysregulation in Heart Failure and Diabetic Cardiomyopathy
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P2860
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@en
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
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type
label
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@en
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@nl
prefLabel
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@en
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@nl
P2093
P2860
P356
P1476
SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states.
@en
P2093
Ferhaan Ahmad
Kenneth R McGaffin
Núria M Pastor-Soler
Sanjay K Banerjee
P2860
P304
P356
10.1093/CVR/CVP190
P577
2009-06-09T00:00:00Z