A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer.
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Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosisThe Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) ProdrugsTransition Metal Intercalators as Anticancer Agents-Recent AdvancesComparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agentsDesign and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agentPhotoinduced intercalation and coordination of a dirhodium complex to DNA: dual DNA binding.Highly selective and sensitive fluorescence detection of Zn(2+) and Cd(2+) ions by using an acridine sensor.Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups.Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agentsUsing a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agentsDesign of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent.Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study.Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay.Photoinduced interactions of two dirhodium complexes with d(GTCGAC)2 probed by 2D NOESY.Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor AgentReplacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung CancerAnalysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cellsSynthesis, characterization, and evaluation of cis-diphenyl pyridineamine platinum(II) complexes as potential anti-breast cancer agentsSynthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents.Cellular Recognition and Repair of Monofunctional-Intercalative Platinum--DNA AdductsDesign of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.PT-ACRAMTU, a platinum-acridine anticancer agent, lengthens and aggregates, but does not stiffen or soften DNA.Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfurSynthetic methods for the preparation of platinum anticancer complexes.Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs.Metal complex interactions with DNA.The potential of combi-molecules with DNA-damaging function as anticancer agents.New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2'-bipyridine and 2,2'-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity.Synthesis and analysis of the anticancer activity of platinum(II) complexes incorporating dipyridoquinoxaline variants.Impact of metal on the DNA photocleavage activity and cytotoxicity of ferrocenyl terpyridine 3d metal complexes.Monofunctional platinum complexes containing a 4-nitrobenzo-2-oxa-1,3-diazole fluorophore: distribution in tumour cells.A tetrazolato-bridged dinuclear platinum(II) complex exhibits markedly high in vivo antitumor activity against pancreatic cancer.Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents.Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting.Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum-Acridine Anticancer Agent.Affinity of a mononuclear monofunctional anticancer Pt(II) complex to human serum albumin: a spectroscopic approach.
P2860
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P2860
A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@en
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@nl
type
label
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@en
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@nl
prefLabel
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@en
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@nl
P2093
P2860
P356
P1476
A non-cross-linking platinum-a ...... in non-small-cell lung cancer.
@en
P2093
Cynthia S Day
Gilda Saluta
Gregory L Kucera
Jayati Roy Choudhury
Marcus W Wright
Ulrich Bierbach
Zhidong Ma
P2860
P304
P356
10.1021/JM800900G
P407
P577
2008-12-01T00:00:00Z