Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
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Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsStructure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.Forkhead box M1 transcription factor: a novel target for cancer therapy.Femtosecond crystallography of membrane proteins in the lipidic cubic phase.Targeting Hedgehog--a cancer stem cell pathwaySmall-molecule modulators of the Sonic Hedgehog signaling pathway.Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.Enhancement of cyclopamine via conjugation with nonmetabolic sugarsBMI1 polycomb group protein acts as a master switch for growth and death of tumor cells: regulates TCF4-transcriptional factor-induced BCL2 signaling.Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.Small molecule Hedgehog pathway antagonists.Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.Prevention of pancreatic cancer in a hamster model by cAMP decrease.The Hedgehog signalling pathway as a therapeutic target in early breast cancer development.The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers.Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.Cancer stem cells: characteristics and their potential role for new therapeutic strategies.Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.Hedgehog inhibitors: a patent review (2013 - present).Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors.Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway.Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway.Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.Discovery of NVP-LDE225, a Potent and Selective Smoothened AntagonistA hedgehog survival pathway in 'undead' lipotoxic hepatocytes.Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations.Molecular basis of basal cell carcinoma.Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Strategies to target the Hedgehog signaling pathway for cancer therapy.Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor.Hedgehog/Gli1 signal pathway facilitates proliferation, invasion, and migration of cutaneous SCC through regulating VEGF.A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.Catalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling.The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling PathwayHedgehog signalling pathway inhibitors as cancer suppressing agentsThe "Yin and Yang" of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
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Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@en
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@nl
type
label
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@en
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@nl
prefLabel
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@en
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
@nl
P2860
P356
P1476
Hedgehog-Gli signaling pathway inhibitors as anticancer agents
@en
P2093
Chandanamali Punchihewa
Naoaki Fujii
P2860
P304
P356
10.1021/JM801420Y
P407
P577
2009-07-01T00:00:00Z