Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs - Wikidata - awgldk - TriplyDB

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

http://www.wikidata.org/entity/Q27684635

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Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders Structural Studies of G Protein-Coupled Receptors Large-scale production and protein engineering of G protein-coupled receptors for structural studies Novel Allosteric Modulators of G Protein-coupled Receptors Generic GPCR residue numbers - aligning topology maps while minding the gaps Structural basis of Smoothened regulation by its extracellular domains Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications Smoothened goes molecular: new pieces in the hedgehog signaling puzzle G protein-coupled receptors in cardiac biology: old and new receptors Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Smoothened Regulation: A Tale of Two Signals.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Identification of Novel Smoothened Ligands Using Structure-Based Docking.Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas.7TM Domain Structure of Adhesion GPCRs.Wnt signaling in triple-negative breast cancer.Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges.Assessment of the transmembrane domain structures in GPCR Dock 2013 models.Discovery of new GPCR ligands to illuminate new biology.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?Current and Future Challenges in GPCR Drug Discovery.Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors.Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains.A synthetic combinatorial approach to disabling deviant Hedgehog signaling.Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.

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Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

http://www.wikidata.org/entity/Q27684635

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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type

label

Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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prefLabel

Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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Structural basis for Smoothene ...... resistance to anticancer drugs

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Nature Communications

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Structural basis for Smoothene ...... resistance to anticancer drugs

@en

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Bryan L Roth

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Chong Wang

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Dan J Urban

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Eyal Vardy

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Gye Won Han

http://www.w3.org/2001/XMLSchema#string

Marc G Caron

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Sandy J Hufeisen

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Tama Evron

http://www.w3.org/2001/XMLSchema#string

Thomas J Mangano

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of an agonist-bound human A2A adenosine receptor

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

Activating Smoothened mutations in sporadic basal-cell carcinoma

Small molecule modulation of Smoothened activity

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

Crystal structure of the β2 adrenergic receptor-Gs protein complex

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Processing of X-ray diffraction data collected in oscillation mode

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4355

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3138030

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10.1038/NCOMMS5355

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5

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Vsevolod Katritch

Raymond C Stevens

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2014-07-10T00:00:00Z

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1045497145

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25008467

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4198951

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