The arrhythmogenic consequences of increasing late INa in the cardiomyocyte. - Wikidata - awgldk - TriplyDB

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

http://www.wikidata.org/entity/Q37345048

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Ranolazine: A Contemporary Review Ranolazine in Cardiac Arrhythmia The role of late I Na in development of cardiac arrhythmias CaMKII regulation of cardiac K channels CaMKII-dependent regulation of cardiac Na(+) homeostasis Na+ channel function, regulation, structure, trafficking and sequestration α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias The high frequency relationship: implications for torsadogenic hERG blockers.Reduced immunoreactivities of B-type natriuretic peptide in pulmonary arterial hypertension rats after ranolazine treatment A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine.Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).Congenital long QT syndromes: prevalence, pathophysiology and management.Passive ventricular remodeling in cardiac disease: focus on heterogeneity.Late sodium current: A mechanism for angina, heart failure, and arrhythmia.The late sodium current in heart failure: pathophysiology and clinical relevance.High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes.Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy.The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations Larger late sodium current density as well as greater sensitivities to ATX II and ranolazine in rabbit left atrial than left ventricular myocytes.Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin.Evaluation of cardiac electrophysiological properties in an experimental model of right ventricular hypertrophy and failure.CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging.Late sodium current associated cardiac electrophysiological and mechanical dysfunction.Barbaloin inhibits ventricular arrhythmias in rabbits by modulating voltage-gated ion channels.Late sodium current dysregulation as a causal factor in arrhythmia.Protein kinase C and Ca(2+) -calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit ventricular myocytes.Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.Therapeutic Effects of Wenxin Keli in Cardiovascular Diseases: An Experimental and Mechanism Overview Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels

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P2860

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

http://www.wikidata.org/entity/Q37345048

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 June 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@en

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@nl

type

label

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@en

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@nl

prefLabel

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@en

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

@nl

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Cardiovascular Research

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The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

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P2093

John C Shryock

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Luiz Belardinelli

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Sridharan Rajamani

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Yejia Song

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P2860

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

Dispersion of cardiac action potential duration and the initiation of re-entry: a computational study.

Distribution of a persistent sodium current across the ventricular wall in guinea pigs

The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres

Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure

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600-611

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scholarly article

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10.1093/CVR/CVT145

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4

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99

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Charles Antzelevitch

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2013-06-10T00:00:00Z

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23752976

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3841414

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