Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.
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Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cellsThe plasminogen activator inhibitor-2 gene is not required for normal murine development or survivalMicroarray profile of differentially expressed genes in a monkey model of allergic asthmaCurrent concepts in the pathogenesis of chronic thromboembolic pulmonary hypertensionReciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosisAlways cleave up your mess: targeting collagen degradation to treat tissue fibrosisThe Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosisMechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signalingGenetically manipulated mouse models of lung disease: potential and pitfallsGelatinase B is required for alveolar bronchiolization after intratracheal bleomycinGlobal gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosissiRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in ratsIncreased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in micePAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injuryPeriostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis.TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling.Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis.Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture.Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.Plasminogen activator inhibitor-1 and the kidney.Lung fibrosis.Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism.Fibrin turnover in lung inflammation and neoplasia.A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates.Anticoagulants for acute respiratory distress syndrome: can they work?Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo.A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia.The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment.Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury.Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis.TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.Role of the urokinase-fibrinolytic system in epithelial-mesenchymal transition during lung injury.Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice
P2860
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P2860
Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@en
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@nl
type
label
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@en
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@nl
prefLabel
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@en
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@nl
P2093
P2860
P356
P1476
Bleomycin-induced pulmonary fi ...... en activator inhibitor-1 gene.
@en
P2093
D Ginsburg
D T Eitzman
P2860
P304
P356
10.1172/JCI118396
P407
P577
1996-01-01T00:00:00Z