Piecing together the structure of retroviral integrase, an important target in AIDS therapy
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Retroviral intasome assembly and inhibition of DNA strand transferStructural basis for functional tetramerization of lentiviral integraseA Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric AssemblyThe Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally CriticalLocalization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysisRetroviral DNA IntegrationStructural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase.Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingSolution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.Critical appraisal of elvitegravir in the treatment of HIV-1/AIDS.Predicting protein-DNA interactions by full search computational docking.The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide elementChanges in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.HIV-1 IN inhibitors: 2010 update and perspectivesBiochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravirSolution conformation and dynamics of the HIV-1 integrase core domain.Resistance to integrase inhibitors.DDE transposases: Structural similarity and diversityA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.Intasome architecture and chromatin density modulate retroviral integration into nucleosomeRetroviral integration site selection.The removal of RNA primers from DNA synthesized by the reverse transcriptase of the retrotransposon Tf1 is stimulated by Tf1 integraseHIV DNA integration.The molecular biology of HIV integrase.C-Terminal Domain of Integrase Binds between the Two Active SitesRaltegravir: molecular basis of its mechanism of actionThe structural biology of HIV-1: mechanistic and therapeutic insightsStructural biology of retroviral DNA integration.The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.Structural and functional insights into foamy viral integraseComputational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integraseThe Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsThe emerging diversity of transpososome architectures.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).HIV-1 integrase multimerization as a therapeutic target.Retroviral integrase protein and intasome nucleoprotein complex structures.The conformational feasibility for the formation of reaching dimer in ASV and HIV integrase: a molecular dynamics study.Targeted transgene insertion into the CHO cell genome using Cre recombinase-incorporating integrase-defective retroviral vectors.Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence.
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Piecing together the structure of retroviral integrase, an important target in AIDS therapy
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Piecing together the structure ...... portant target in AIDS therapy
@en
Piecing together the structure ...... ortant target in AIDS therapy.
@nl
type
label
Piecing together the structure ...... portant target in AIDS therapy
@en
Piecing together the structure ...... ortant target in AIDS therapy.
@nl
prefLabel
Piecing together the structure ...... portant target in AIDS therapy
@en
Piecing together the structure ...... ortant target in AIDS therapy.
@nl
P2860
P1433
P1476
Piecing together the structure ...... portant target in AIDS therapy
@en
P2093
Alexander Wlodawer
Jerry N Alexandratos
P2860
P304
P356
10.1111/J.1742-4658.2009.07009.X
P407
P577
2009-04-14T00:00:00Z