Structural basis for functional tetramerization of lentiviral integrase - Wikidata - awgldk - TriplyDB

Structural basis for functional tetramerization of lentiviral integrase

Structural basis for functional tetramerization of lentiviral integrase

http://www.wikidata.org/entity/Q27316560

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Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Retroviral intasome assembly and inhibition of DNA strand transfer Novel therapeutic strategies targeting HIV integrase Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical Retroviral Integrase: Then and Now Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase Retroviral DNA Integration Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide element Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.Structure-based modeling of the functional HIV-1 intasome and its inhibition Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development.A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Molecular mechanisms of retroviral integration site selection.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.Retroviral integrase proteins and HIV-1 DNA integration Retroviral Integrase Structure and DNA Recombination Mechanism HIV DNA is heavily uracilated, which protects it from autointegration Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.Retroviral integration site selection.Uneven genetic robustness of HIV-1 integrase.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration.Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.Murine leukemia viruses: objects and organisms.In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors.Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.Architecture and assembly of HIV integrase multimers in the absence of DNA substrates Structural biology of retroviral DNA integration.

P2860

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P2860

Structural basis for functional tetramerization of lentiviral integrase

http://www.wikidata.org/entity/Q27316560

description

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

article scientifique (publié 2009-07)

@fr

articolo scientifico (pubblicato il 2009-07)

@it

artigo científico (publicado na 2009-07)

@pt

artículu científicu espublizáu en 2009

@ast

im Juli 2009 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: July 2009)

@en

vedecký článok (publikovaný 2009-07)

@sk

videnskabelig artikel (udgivet 2009-07)

@da

name

Structural basis for functional tetramerization of lentiviral integrase

@ast

Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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type

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Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Structural Basis for Functional Tetramerization of Lentiviral Integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Structural basis for functional tetramerization of lentiviral integrase

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Alan Engelman

http://www.w3.org/2001/XMLSchema#string

Alfred Labeja

http://www.w3.org/2001/XMLSchema#string

Francesca Di Nunzio

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Jimin Wang

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Stephen Hare

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P2860

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

The morph server: a standardized system for analyzing and visualizing macromolecular motions in a database framework.

HIV-1 integrase crosslinked oligomers are active in vitro

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

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10.1371/JOURNAL.PPAT.1000515

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7

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26677133

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