Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. - Wikidata - awgldk - TriplyDB

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

http://www.wikidata.org/entity/Q37354141

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Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes In vitro culture of functionally active buffalo hepatocytes isolated by using a simplified manual perfusion method Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro Engineering hydrogels as extracellular matrix mimics Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function.Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. [corrected]How multi-organ microdevices can help foster drug development Metabolic profiling based quantitative evaluation of hepatocellular metabolism in presence of adipocyte derived extracellular matrix.Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.In vitro platforms for evaluating liver toxicity.Polyelectrolyte multilayers in tissue engineering.A whole-organ regenerative medicine approach for liver replacement.Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.Generation of Self-Renewing Hepatoblasts From Human Embryonic Stem Cells by Chemical Approaches Serum-free medium and mesenchymal stromal cells enhance functionality and stabilize integrity of rat hepatocyte spheroids.Long-term culture and coculture of primary rat and human hepatocytes Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells.Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis.Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity.Microfluidic platforms for hepatocyte cell culture: new technologies and applications.The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips.Organotypic systems in drug metabolism and toxicity: challenges and opportunities.Biomaterials for liver tissue engineering.Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures.Three-dimensional culture of a genetically modified hepatoma cell line using macroporous gelatin beads.Use of Primary Rat Hepatocytes for Prediction of Drug-Induced Mitochondrial Dysfunction.Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signalling.The application of cell sheet engineering in the vascularization of tissue regeneration.Technical aspects of oxygen level regulation in primary cell cultures: A review.Future of bioartificial liver support.Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device.Long-term hepatitis B infection in a scalable hepatic co-culture system.Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection.Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes.Long-term culture and expansion of primary human hepatocytes.Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor.

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Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.

http://www.wikidata.org/entity/Q37354141

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article científic

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bilimsel makale

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scientific article published on 31 August 2009

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Oxygen-mediated enhancement of ...... xpression, and drug clearance.

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PNAS.0906820106

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Proceedings of the National Academy of Sciences of the United States of America

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Oxygen-mediated enhancement of ...... expression, and drug clearance

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Eric Novik

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Martin L Yarmush

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Piyun Chao

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Rubin S Yarmush

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P2860

Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds

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The value of improving the productivity of the drug development process: faster times and better decisions

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere.

3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.

Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.

Economic evaluation of vaccination programmes: a consensus statement focusing on viral hepatitis.

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

Making better drugs: Decision gates in non-clinical drug development.

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15714-15719

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106

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Srivatsan Kidambi

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26780638

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19720996

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2747185

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