Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. - Wikidata - awgldk - TriplyDB

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

http://www.wikidata.org/entity/Q37355444

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PGC-1α, mitochondrial dysfunction, and Huntington's disease Mitochondrial DNA damage induced autophagy, cell death, and disease The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease Mitochondrial Biology and Neurological Diseases Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease Metabolism in HD: still a relevant mechanism?Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress Angiotensins and Huntington's Disease: A Study on Immortalized Progenitor Striatal Cell Lines.Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions Oxidative stress, mitochondrial damage and neurodegenerative diseases Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with systemic lupus erythematosus Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.The role of mitochondrial DNA mutation on neurodegenerative diseases.Detection of DNA damage in peripheral blood mononuclear cells from pancreatic cancer patients Oxidative metabolism in YAC128 mouse model of Huntington's disease.Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival.8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line.Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Antioxidant gene therapy against neuronal cell death.DNA repair mechanisms in Huntington's disease.Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases.Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling.The role of DNA base excision repair in brain homeostasis and disease.The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8).Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease.A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease

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Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

http://www.wikidata.org/entity/Q37355444

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scientific article published on 16 June 2012

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J.FREERADBIOMED.2012.06.008

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Free Radical Biology and Medicine

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Mitochondrial DNA damage is as ...... getics in Huntington's disease

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Almas Siddiqui

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Anand Rane

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Carlos A Torres-Ramos

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David G Nicholls

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Karina Acevedo-Torres

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María del R Castro

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Sulay Rivera-Sánchez

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Sylvette Ayala-Torres

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P2860

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

Identification of redox/repair protein Ref-1 as a potent activator of p53

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

Mitochondrial localization of APE/Ref-1 in thyroid cells

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Efficient repair of abasic sites in DNA by mitochondrial enzymes.

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1478-1488

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scholarly article

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10.1016/J.FREERADBIOMED.2012.06.008

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7

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53

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Julie K Andersen

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2012-06-16T00:00:00Z

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227341312

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22709585

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Huntington disease

mitochondrial DNA

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3846402

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