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Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentialsDifferential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naïve patients with type 2 diabetesTCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liverAlternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.Evidence for neuroendocrine function of a unique splicing form of TCF7L2 in human brain, islets and gut.Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansHeparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling.NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibilityTwo novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver.An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes.Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico.Implications of polyadenylation in health and disease.The role of the Wnt signaling pathway in incretin hormone production and function.The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspectiveAdipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism.Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.Crosstalk between Wnt Signaling and RNA Processing in Colorectal Cancer.Animal models of GWAS-identified type 2 diabetes genes.Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins.Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study.Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.Messenger RNA processing and its role in diabetes.TCF/LEFs and Wnt signaling in the nucleus.Regulation of alternative splicing in obesity and weight loss.Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes.Alternative splicing as a biomarker and potential target for drug discovery.Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line.Alternative splicing and the evolution of phenotypic novelty.The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.TCF7L2 splice variants have distinct effects on beta-cell turnover and function.Evidence of selection on splicing-associated loci in human populations and relevance to disease loci mapping.
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P2860
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 July 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tissue-specific alternative splicing of TCF7L2.
@en
Tissue-specific alternative splicing of TCF7L2.
@nl
type
label
Tissue-specific alternative splicing of TCF7L2.
@en
Tissue-specific alternative splicing of TCF7L2.
@nl
prefLabel
Tissue-specific alternative splicing of TCF7L2.
@en
Tissue-specific alternative splicing of TCF7L2.
@nl
P2093
P2860
P50
P356
P1476
Tissue-specific alternative splicing of TCF7L2.
@en
P2093
Andrew Sprau
Brennan Harmon
Cullan Welch
Eric P Hoffman
Jennifer L Hall
Laura J Scott
Maurine Tong
Michael R Erdos
Neeta Adhikari
P2860
P304
P356
10.1093/HMG/DDP321
P50
P577
2009-07-14T00:00:00Z