YAP: at the crossroad between transformation and tumor suppression.
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Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativityRaf family kinases: old dogs have learned new tricks14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 geneThe MST/Hippo Pathway and Cell Death: A Non-Canonical AffairThe tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injuryThe role of the Hippo pathway in human disease and tumorigenesisCytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.The Hippo pathway in disease and therapy: cancer and beyondDown-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells.YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancerNovel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells.Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning.Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions.YAP regulates S-phase entry in endothelial cellsAlcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophilagga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection.Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch.Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomasPrognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis.Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptorsYAP is a critical oncogene in human cholangiocarcinomaOncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activationPML Surfs into HIPPO Tumor Suppressor Pathway.Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinomaEffect of YAP1 silencing on esophageal cancer.ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase.Yorkie: the final destination of Hippo signaling.Mammalian Hippo pathway: from development to cancer and beyond.Hippo signaling in Drosophila: recent advances and insightsIntegration of intercellular signaling through the Hippo pathwayThe dual functions of YAP-1 to promote and inhibit cell growth in human malignancy.LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
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YAP: at the crossroad between transformation and tumor suppression.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 24 January 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
YAP: at the crossroad between transformation and tumor suppression.
@en
YAP: at the crossroad between transformation and tumor suppression.
@nl
type
label
YAP: at the crossroad between transformation and tumor suppression.
@en
YAP: at the crossroad between transformation and tumor suppression.
@nl
prefLabel
YAP: at the crossroad between transformation and tumor suppression.
@en
YAP: at the crossroad between transformation and tumor suppression.
@nl
P2093
P356
P1433
P1476
YAP: at the crossroad between transformation and tumor suppression.
@en
P2093
Efrem Bertini
Giovanni Blandino
Marius Sudol
Sabrina Strano
Tsutomu Oka
P356
10.4161/CC.8.1.7259
P577
2009-01-24T00:00:00Z