Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry
about
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionStructure/Function Relationships of Adipose Phospholipase A2 Containing a Cys-His-His Catalytic TriadInsertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulationsChanges in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX.Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimerDetection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometryAmide hydrogen/deuterium exchange & MALDI-TOF mass spectrometry analysis of Pak2 activation.DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substratesDynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110αApplications of mass spectrometry to lipids and membranesOncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoformStructural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometryUsing hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes.Membrane and inhibitor interactions of intracellular phospholipases A2.Inhibition of iPLA2 β and of stretch-activated channels by doxorubicin alters dystrophic muscle function.Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.Phospholipases A2 and inflammatory responses in the central nervous system.Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.Substrate efflux propensity is the key determinant of Ca2+-independent phospholipase A-β (iPLAβ)-mediated glycerophospholipid hydrolysisLipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix.Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry.Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.Structural analysis of diheme cytochrome c by hydrogen-deuterium exchange mass spectrometry and homology modelingCalcium-independent phospholipases A2 in murine osteoblastic cells and their inhibition by bromoenol lactone: impact on arachidonate dynamics and prostaglandin synthesis.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization.Conformational Dynamics and Interactions of Membrane Proteins by Hydrogen/Deuterium Mass Spectrometry.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
P2860
Q26997377-9D6D6C2A-B9EB-4BB0-8399-E8153E651A69Q27671706-16731E80-31FD-4041-AEEA-2750A613822BQ28534839-C9B8228A-8776-4926-8CA8-4F1604283E48Q30153398-5D181AE3-264C-4131-8538-5A69C0CE7CB6Q30408410-6E728D9C-46A1-46B6-B268-C46B7471E629Q30497045-79E4E05A-E72C-47B4-ADFC-6E8485082BBBQ33564915-550A9972-CDAB-47EF-83BC-DB7324DA31C9Q34092111-2FD7EEB5-7249-42DB-A3D3-06E316F85D38Q34927801-5F53A0CD-27D7-481A-8415-B91202000BFEQ35090044-4B9BD97C-84F0-416C-AEA4-303B37DE3B01Q35161212-5F20E846-93E6-4052-A080-315E295C5FE1Q36135725-16F84D0B-FBAF-457E-9FC2-B789F69DD678Q36279889-67E6F29D-00F6-48BF-99F9-0721E5C6133AQ36294881-9A5FAC11-8F18-4C8E-8D81-5EF4886CF9F5Q36385891-84D1F19F-0C2C-4544-A85A-E3BE10FABCE1Q36462031-E2E43145-BE69-4CCA-9B81-CEF5C2C82615Q36543771-FAC92FDB-73C1-485A-B64B-15D418B9E142Q36945608-C9AB7033-06F5-4255-9919-96A70F8E5572Q37046769-36CE7B85-C344-4477-8D84-C7AD3F07CCCAQ37228274-1170F0C1-DBFC-43AF-B342-03CF9C149F08Q37421407-3B742BE5-219E-44F6-8DD6-C22165912A41Q37621283-0A7EAEAB-9D8A-409D-B9B9-F677BCF6AFADQ38722497-B66C7D6C-B008-44A5-8C7C-929FBADF7E14Q39671868-F3E21F04-8CEE-4AD8-BEA3-97B2D4849B50Q39715315-D2F9E4BA-13F1-4D72-965A-7DDD7E57C519Q39752661-7DA04662-54F0-4F43-887D-527AAEE1B3A9Q41811238-816C8F02-7981-4A86-87E9-84B25C5CDF82Q42136740-5EFB137E-432D-46DC-9B4C-5236FAB4E877Q42545972-606C6ECC-D51F-404A-AFA3-75250AF29DACQ42817634-720CE4E0-65C2-4A87-B137-5BF7E6FA44B7Q47996927-1F30B302-F50B-4A04-AB0F-CC15822CCED3Q50000395-1B2592C7-FD63-4BCE-8962-431A417D5DB6Q50282174-A686A316-8985-48B3-A427-B898647A275DQ51598528-03EA4F45-A60F-4C20-8D6F-9CDC973B17F7Q52622522-C0C54EDA-4D48-4126-B603-C73485DAD9BA
P2860
Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Localizing the membrane bindin ...... ium exchange mass spectrometry
@en
Localizing the membrane bindin ...... um exchange mass spectrometry.
@nl
type
label
Localizing the membrane bindin ...... ium exchange mass spectrometry
@en
Localizing the membrane bindin ...... um exchange mass spectrometry.
@nl
prefLabel
Localizing the membrane bindin ...... ium exchange mass spectrometry
@en
Localizing the membrane bindin ...... um exchange mass spectrometry.
@nl
P2093
P2860
P356
P1476
Localizing the membrane bindin ...... ium exchange mass spectrometry
@en
P2093
Virgil L Woods
Yuan-Hao Hsu
P2860
P304
23652-23661
P356
10.1074/JBC.M109.021857
P407
P577
2009-06-25T00:00:00Z