The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
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The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionThe expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cellsPhospholipase A2 biochemistryProinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of via phospholipase A2 (iPLA2)Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcriptHighly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity.Calcium-independent phospholipase A2 in rabbit ventricular myocytesGroup VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.Expression of PLA2G6 in human fetal development: Implications for infantile neuroaxonal dystrophy.Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway.Expression and function of phospholipase A(2) in brain.First pass annotation of promoters on human chromosome 22.Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substratesGroup IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation.Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.Membrane and inhibitor interactions of intracellular phospholipases A2.Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation.Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometryRole of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis.Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells.HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange.Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells.Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+.Calcium-independent phospholipases A2 in murine osteoblastic cells and their inhibition by bromoenol lactone: impact on arachidonate dynamics and prostaglandin synthesis.Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer.Regulation of membrane-associated iPLA2 activity by a novel PKC isoform in ventricular myocytes.Ca2+-independent phospholipase A2 is required for agonist-induced Ca2+ sensitization of contraction in vascular smooth muscle.Effect of indomethacin on force responses and sarcoplasmic reticulum function in skinned skeletal muscle fibers and cytosolic [Ca2+] in myotubes.Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity.Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease.Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A-independent transacylase.Serum calcium-independent phospholipase A2 activity in bipolar affective disorder.Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus.Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging.
P2860
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P2860
The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The human calcium-independent ...... properties from a single gene
@ast
The human calcium-independent ...... properties from a single gene
@en
The human calcium-independent ...... properties from a single gene
@nl
type
label
The human calcium-independent ...... properties from a single gene
@ast
The human calcium-independent ...... properties from a single gene
@en
The human calcium-independent ...... properties from a single gene
@nl
prefLabel
The human calcium-independent ...... properties from a single gene
@ast
The human calcium-independent ...... properties from a single gene
@en
The human calcium-independent ...... properties from a single gene
@nl
P2860
P1433
P1476
The human calcium-independent ...... properties from a single gene
@en
P2093
B P Kennedy
P K Larsson Forsell
P2860
P304
P356
10.1046/J.1432-1327.1999.00418.X
P407
P577
1999-06-01T00:00:00Z