Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells - Wikidata - awgldk - TriplyDB

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

http://www.wikidata.org/entity/Q37360904

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hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine Genome Engineering with TALE and CRISPR Systems in Neuroscience Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research Modeling ALS and FTD with iPSC-derived neurons Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes The unexpected co-occurrence of GRN and MAPT p.A152T in Basque families: Clinical and pathological characteristics RNA stores tau reversibly in complex coacervates Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.Investigating human disease using stem cell models.Genomic editing tools to model human diseases with isogenic pluripotent stem cells.Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells.Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery.Advances in reprogramming-based study of neurologic disorders Probing disorders of the nervous system using reprogramming approaches.Using Human iPSC-Derived Neurons to Model TAU Aggregation.Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT Amyloid in dementia associated with familial FTLD: not an innocent bystander.Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development.Human stem cell models of dementia.Neural crest cells: from developmental biology to clinical interventions.Induced pluripotent stem cell technology for modelling and therapy of cerebellar ataxia.Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Gene correction in patient-specific iPSCs for therapy development and disease modeling.Review: Induced pluripotent stem cell models of frontotemporal dementia.ALS/FTLD: experimental models and reality.May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells.Modeling tau pathology in human stem cell derived neurons.Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.The ER under rapid fire.Translational synthetic biology.

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Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

http://www.wikidata.org/entity/Q37360904

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 August 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Genetic correction of tauopath ...... induced pluripotent stem cells

@en

Genetic correction of tauopath ...... nduced pluripotent stem cells.

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type

label

Genetic correction of tauopath ...... induced pluripotent stem cells

@en

Genetic correction of tauopath ...... nduced pluripotent stem cells.

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prefLabel

Genetic correction of tauopath ...... induced pluripotent stem cells

@en

Genetic correction of tauopath ...... nduced pluripotent stem cells.

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J.STEMCR.2013.08.001

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Stem Cell Reports

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Genetic correction of tauopath ...... induced pluripotent stem cells

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Anna Karydas

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Chengzhong Wang

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David Walker

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Helen Fong

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Johanna Knoferle

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Karen L Ring

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Kenneth S Kosik

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Laura Leung

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Leslie M Tong

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Maureen E Balestra

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P2860

Frontotemporal dementias: a review

Alzheimer mechanisms and therapeutic strategies

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

Disease-specific induced pluripotent stem cells

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

An improved zinc-finger nuclease architecture for highly specific genome editing

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

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226-234

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scholarly article

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10.1016/J.STEMCR.2013.08.001

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3

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1

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Bruce L. Miller

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2013-08-29T00:00:00Z

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259250064

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24319659

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Human Induced Pluripotent Stem Cells

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3849235

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