Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. - Wikidata - awgldk - TriplyDB

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

http://www.wikidata.org/entity/Q37362059

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Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In Vitro Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.Local protease signaling contributes to neural tube closure in the mouse embryo Matriptase activation, an early cellular response to acidosis.Matriptase zymogen supports epithelial development, homeostasis and regeneration Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance The level of claudin-7 is reduced as an early event in colorectal carcinogenesis.Membrane-anchored serine proteases in vertebrate cell and developmental biology Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents.The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase Increased matriptase zymogen activation in inflammatory skin disorders.Detection of active matriptase using a biotinylated chloromethyl ketone peptide Matriptase deletion initiates a Sjögren's syndrome-like disease in mice.Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea.Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells Matriptase protects against experimental colitis and promotes intestinal barrier recovery Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1 ZEB1-responsive genes in non-small cell lung cancer Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities.Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Membrane-anchored proteases in endothelial cell biology.A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.Membrane-anchored serine proteases in health and disease.Type II transmembrane serine proteases as potential targets for cancer therapy.Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.

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Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

http://www.wikidata.org/entity/Q37362059

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 28 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@en

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@nl

type

label

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@en

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@nl

prefLabel

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@en

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

@nl

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AJPATH.2009.090240

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The American Journal of Pathology

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Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

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Alexandra L Bey

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Alfredo Molinolo

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Chao Becky Wang

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Karin List

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Peter Kosa

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Roman Szabo

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scholarly article

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10.2353/AJPATH.2009.090240

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4

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