Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. - Wikidata - awgldk - TriplyDB

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

http://www.wikidata.org/entity/Q37363157

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A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models The next generation of risk assessment multiyear study - highlights of findings, applications to risk assessment, and future directions Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes Addressing human variability in next-generation human health risk assessments of environmental chemicals Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis.Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice.Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety.Use of transcriptomics in understanding mechanisms of drug-induced toxicity Differential regulation of mitogen-activated protein kinase pathways by acetaminophen and its nonhepatotoxic regioisomer 3'-hydroxyacetanilide in TAMH cells.A randomized, placebo-controlled trial to determine the course of aminotransferase elevation during prolonged acetaminophen administration.Strain screen and haplotype association mapping of wheel running in inbred mouse strains.Mechanisms of drug-induced liver injury: from bedside to bench.A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.Toxicogenetics: population-based testing of drug and chemical safety in mouse models.Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics.Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.Mouse Phenome Database (MPD)3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity.Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice Genetic screening reveals a link between Wnt signaling and antitubulin drugs.Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression Effect of therapeutic doses of acetaminophen (up to 4 g/day) on serum alanine aminotransferase levels in subjects consuming ethanol: systematic review and meta-analysis of randomized controlled trials.Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen

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Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

http://www.wikidata.org/entity/Q37363157

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Mouse population-guided resequ ...... nduced liver injury in humans.

@en

Mouse population-guided resequ ...... nduced liver injury in humans.

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type

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Mouse population-guided resequ ...... nduced liver injury in humans.

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Mouse population-guided resequ ...... nduced liver injury in humans.

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Mouse population-guided resequ ...... nduced liver injury in humans.

@en

Mouse population-guided resequ ...... nduced liver injury in humans.

@nl

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Genome Research

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Mouse population-guided resequ ...... nduced liver injury in humans.

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Christopher Harris

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David E Harbourt

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Gary A Boorman

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Ioannis M Stylianou

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Ivan Rusyn

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Kenneth Paigen

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Mark W Russo

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Molly Bogue

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Pamela K Ross

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Paul B Watkins

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P2860

Comparative analysis of haplotype association mapping algorithms

Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity

Genetics of gene expression surveyed in maize, mouse and man

The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics.

Genealogies of mouse inbred strains.

Drug-induced liver diseases.

A mouse phenome project.

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

Acute liver failure in the United States.

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

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1507-1515

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scholarly article

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10.1101/GR.090241.108

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9

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19

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David W. Threadgill

Alison H Harrill

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2009-05-05T00:00:00Z

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24403172

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19416960

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2752130

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