Senescence-messaging secretome: SMS-ing cellular stress.
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The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulatorsFeedback between p21 and reactive oxygen production is necessary for cell senescenceCellular senescence controls fibrosis in wound healingThe matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingRole of the microbiome in non-gastrointestinal cancersNoncoding RNA control of cellular senescenceMolecular turnover, the H3.3 dilemma and organismal aging (hypothesis)Roles and mechanisms of cellular senescence in regulation of tissue homeostasisMultifocal epithelial tumors and field cancerization: stroma as a primary determinantNF-κB in cellular senescence and cancer treatmentCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventionsRedox control of senescence and age-related diseaseDNA Damage: From Chronic Inflammation to Age-Related DeteriorationRetinoids induce cellular senescence in breast cancer cells by RAR-β dependent and independent pathways: Potential clinical implications (Review)Stress induced premature senescence: a new culprit in ovarian tumorigenesis?A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationEsophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cellsUpregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinomaAging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cellsThe senescence-associated secretory phenotype: the dark side of tumor suppressionRAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma developmentNOTCH1 mediates a switch between two distinct secretomes during senescence.Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts.PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage inDNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretioncGAS is essential for cellular senescence.Cellular senescence drives age-dependent hepatic steatosis.Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation.Lineage-specific restraint of pituitary gonadotroph cell adenoma growth.Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters.Inflammatory networks during cellular senescence: causes and consequences.Cell senescence in myxoid/round cell liposarcomaModulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells.CCN1/CYR61: the very model of a modern matricellular protein.A complex secretory program orchestrated by the inflammasome controls paracrine senescence.The role of senescent cells in ageing.Mitochondria are required for pro-ageing features of the senescent phenotype.
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Senescence-messaging secretome: SMS-ing cellular stress.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 09 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Senescence-messaging secretome: SMS-ing cellular stress.
@en
Senescence-messaging secretome: SMS-ing cellular stress.
@nl
type
label
Senescence-messaging secretome: SMS-ing cellular stress.
@en
Senescence-messaging secretome: SMS-ing cellular stress.
@nl
prefLabel
Senescence-messaging secretome: SMS-ing cellular stress.
@en
Senescence-messaging secretome: SMS-ing cellular stress.
@nl
P356
P1476
Senescence-messaging secretome: SMS-ing cellular stress.
@en
P2093
Daniel S Peeper
Thomas Kuilman
P2888
P356
10.1038/NRC2560
P407
P577
2009-01-09T00:00:00Z