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The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone lossTLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem DiagnosisCirculating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune DiseasesActivated Complement Factors as Disease Markers for SepsisMolecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"?Host innate immune responses to sepsisThe role of complement system in septic shockThe complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsisA recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritisComplement: a key system for immune surveillance and homeostasisNOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis.C5a regulates IL-12+ DC migration to induce pathogenic Th1 and Th17 cells in sepsis.Identification of conformational epitopes for human IgG on Chemotaxis inhibitory protein of Staphylococcus aureus.C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach.Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathwaysResolvin D2 is a potent regulator of leukocytes and controls microbial sepsisEarly release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion.Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's diseaseThe Controversial C5a Receptor C5aR2: Its Role in Health and Disease.Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microgliaSpatiotemporal dynamics of complement C5a production within bacterial extracellular polymeric substanceComplement activation in emergency department patients with severe sepsisAbsence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.Deficiency of C5aR prolongs renal allograft survival.The complement systemSphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxinComplementing the inflammasome.HMGB1 in health and disease.Deficiency of C5L2 increases macrophage infiltration and alters adipose tissue function in mice.C5a receptor deficiency alters energy utilization and fat storage.Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plagueA pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation.Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice.The role of the anaphylatoxins in health and disease.Complement dependency of cardiomyocyte release of mediators during sepsisPost challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Functional roles for C5a receptors in sepsis
@en
Functional roles for C5a receptors in sepsis.
@nl
type
label
Functional roles for C5a receptors in sepsis
@en
Functional roles for C5a receptors in sepsis.
@nl
prefLabel
Functional roles for C5a receptors in sepsis
@en
Functional roles for C5a receptors in sepsis.
@nl
P2093
P2860
P50
P356
P1433
P1476
Functional roles for C5a receptors in sepsis
@en
P2093
Brian A Nadeau
Charles R Mackay
Craig Gerard
Danielle E Day
J Vidya Sarma
Michael A Flierl
Norma P Gerard
P2860
P2888
P304
P356
10.1038/NM1753
P407
P577
2008-05-04T00:00:00Z