Biased agonism as a mechanism for differential signaling by chemokine receptors.
about
Allosteric Modulation of Chemoattractant ReceptorsBiased and g protein-independent signaling of chemokine receptorsBiological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivityChemokines as effector and target molecules in vascular biologyCC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.Biased signaling at chemokine receptorsFunctional Divergence in the Role of N-Linked Glycosylation in Smoothened SignalingQuantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine AbuseA Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders.Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators.Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?Overview and potential unifying themes of the atypical chemokine receptor family.An overview of pharmacodynamic modelling, ligand-binding approach and its application in clinical practiceNew paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Dynamin function is important for chemokine receptor-induced cell migration.Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays.New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.GPCR desensitization: Acute and prolonged phases.Mechanisms of Regulation of the Chemokine-Receptor Network.Pancreatic islet inflammation: an emerging role for chemokines.CXC Chemokine Receptor 3 Alternative Splice Variants Selectively Activate Different Signaling Pathways.Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function.Biased signalling: from simple switches to allosteric microprocessors.Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.Ligand-specific conformational transitions and intracellular transport required for atypical chemokine receptor 3-mediated chemokine scavenging.Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3.Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5.Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways.The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
P2860
Q26747395-2E65541B-B64F-451F-9689-C2EBF3666D4DQ26823970-4CEDD9C1-61B2-4EB9-976D-F3A396EC7569Q27021347-154EC7FE-C1C6-403C-8EFF-1830EC248937Q27024341-D98FC5C3-588E-4E4A-B2D4-5F31A971CABEQ29147492-5D40A50C-74FB-4DCE-B63D-943F0EE36126Q33846502-DB2A23E9-7102-4556-80AA-352DB27A57E1Q35351711-733803E1-E503-4C81-9A56-0A60B5A2DCB4Q35751142-66B38FA5-7C57-498D-BE3E-E724B710C03DQ35999761-57ED43EB-17E4-400B-974B-EABBB0DB1798Q37099122-6968C22B-26DF-4FA4-90BF-179CF4D490A6Q37310521-CA6EDD57-A4DD-4982-A2C9-52A541EAA36DQ38445448-6DAC49EB-35B2-4004-843C-C6CE54F708E6Q38678404-37423518-5775-4743-A05D-0FB355DCC24AQ38689110-8A37B012-05A1-4B71-9692-0B2D4EF71419Q38739512-15AEE839-A823-412D-ABFB-685F3CBA2AEEQ38815332-0C16DBD6-A6D1-4310-9642-C844DC46895DQ38836861-14D8EA4D-4DB5-4842-BA09-A8A60A1C257FQ38866310-7A54FAEB-9D30-4413-AFA6-09E8DFB5A568Q38978556-F8C2615F-68FD-4148-AC1E-D0B469B84D55Q39004795-E36A641B-C072-4B5F-AE02-C52755E49DDAQ39110070-5347E24D-6E44-4DE6-A5DF-8DB0DB5C5F8FQ39126530-BA83FF88-613A-438D-959C-886299864A49Q39249398-625B9E91-1DD9-4A03-8142-6B6E30D71634Q39501428-AC7B4BAE-B8BC-4A9C-9FEC-5C4CABEE5C67Q40925445-4E776482-25F6-4B80-A9B9-A25D22088FABQ47231111-C6A8975D-92E1-44E9-8644-1E30B2217651Q47260364-DDA194CD-C624-4C13-BE96-4507FF30AA37Q47358910-B41FA3CA-F034-4949-BC36-3BFD19D85942Q47719808-6A866BA2-AC1F-4D98-9821-077C61477820Q48193375-E3A40C80-1FFE-43ED-A8F9-2A8344650763Q49524220-F078107B-3D36-4045-AA60-0899B5106208Q50970453-24DA5C88-23AA-46D0-BF69-8CFAAE2DB37CQ55155725-7F2185BB-829C-49E5-BD92-DF76D8BD55D7Q57118375-23E28A88-5E38-4853-B0AF-77685EE4C0A7
P2860
Biased agonism as a mechanism for differential signaling by chemokine receptors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 October 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@en
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@nl
type
label
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@en
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@nl
prefLabel
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@en
Biased agonism as a mechanism for differential signaling by chemokine receptors.
@nl
P2093
P2860
P356
P1476
Biased agonism as a mechanism for differential signaling by chemokine receptors
@en
P2093
Craig Gerard
Daniel L Bassoni
Norma P Gerard
Tom S Wehrman
P2860
P304
35039-35048
P356
10.1074/JBC.M113.479113
P407
P577
2013-10-21T00:00:00Z