Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety AssessmentThe role of concentration-effect relationships in the assessment of QTc interval prolongationDrug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trialsModel-based evaluation of drug-induced QTc prolongation for compounds in early development.Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.Predicting QRS and PR interval prolongations in humans using nonclinical data.Gastrointestinal dysmotility disorders in critically ill dogs and cats.Characterizing QT interval prolongation in early clinical development: a case study with methadone.Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans.The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments.Translating QT interval prolongation from conscious dogs to humans.Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies.Model-based prediction of the acute and long-term safety profile of naproxen in rats.Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation.Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities.Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
P2860
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P2860
Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
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2013 nî lūn-bûn
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2013年学术文章
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name
Identifying the translational ...... ced QTc interval prolongation.
@en
Identifying the translational ...... ced QTc interval prolongation.
@nl
type
label
Identifying the translational ...... ced QTc interval prolongation.
@en
Identifying the translational ...... ced QTc interval prolongation.
@nl
prefLabel
Identifying the translational ...... ced QTc interval prolongation.
@en
Identifying the translational ...... ced QTc interval prolongation.
@nl
P2093
P2860
P356
P1476
Identifying the translational ...... ced QTc interval prolongation.
@en
P2093
Anne S Y Chain
Cardiovascular Safety Project Team, TI Pharma PKPD Platform
Meindert Danhof
Miriam C J M Sturkenboom
Oscar Della Pasqua
Vincent F S Dubois
P2860
P304
P356
10.1111/BCP.12082
P407
P577
2013-11-01T00:00:00Z