Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

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http://www.wikidata.org/entity/Q37369777

Q37369777

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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2 Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer Antiangiogenic mechanisms and factors in breast cancer treatment Proteoglycans in liver cancer The biology of small leucine-rich proteoglycans in bone pathophysiology Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope Transcriptional silencing of perlecan gene expression by interferon-gamma Decorin is a biological ligand for the epidermal growth factor receptor Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells.Biologically active decorin is a monomer in solution.Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation Decorin deficiency promotes hepatic carcinogenesis Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells Potential dual immunomodulatory role of VEGF in ulcerative colitis and colorectal carcinoma Conformational nature of the Borrelia burgdorferi decorin binding protein A epitopes that elicit protective antibodies Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.Mechano-regulation of collagen biosynthesis in periodontal ligament.Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy Proteoglycan and collagen expression during human air conducting system development.Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breast.Decorin as a multivalent therapeutic agent against cancer.Stromal accumulation of chondroitin sulphate in mammary tumours of dogs.Structural change in decorin with skin aging.Differential expression of decorin by human malignant and benign vascular tumors.Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1.Dichotomy of decorin activity on the insulin-like growth factor-I system Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis.An antimetastatic role for decorin in breast cancer.Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis

P2860

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P2860

Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

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http://www.wikidata.org/entity/Q37369777

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 1997

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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