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Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease ProgressionSmall is beautiful: insulin-like growth factors and their role in growth, development, and cancerDural metastasis of Ewing's sarcoma.Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.Does insulin-like growth factor 1 receptor (IGF-1R) targeting provide new treatment options for chordomas? A retrospective clinical and immunohistochemical study.Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growthOverlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomasR1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axisSafety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study.New therapeutic targets in soft tissue sarcoma.Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma.The molecular pathogenesis of osteosarcoma: a reviewOncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment.Emerging therapeutic targets for synovial sarcoma.Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program.Malignant phyllodes tumor of the breast presenting with hypoglycemia: a case report and literature review.IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma.Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507.Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma.Association between height and malignancy among children in the north of Iran.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis.Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma.Targeted therapy in Ewing sarcoma.New systemic therapy options for advanced sarcomas.A set of imprinted genes required for normal body growth also promotes growth of rhabdomyosarcoma cells.Clinical development of insulin-like growth factor receptor--1 (IGF-1R) inhibitors: at the crossroad?Tissue and serum IGFBP7 protein as biomarker in high-grade soft tissue sarcomaNew drugs and combinations for the treatment of soft-tissue sarcoma: a review.RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.Non-islet cell tumour hypoglycaemia: A case report.New medical treatment options and strategies to assess clinical outcome in soft-tissue sarcoma.Molecular and cellular biology of rhabdomyosarcoma.Growth factors as active participants in carcinogenesis: a perspective.Past, present and future of therapies in pediatric sarcomas.Soft tissue sarcomas in children.Systemic management strategies for metastatic soft tissue sarcoma.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The insulin-like growth factor system and sarcomas.
@en
The insulin-like growth factor system and sarcomas.
@nl
type
label
The insulin-like growth factor system and sarcomas.
@en
The insulin-like growth factor system and sarcomas.
@nl
prefLabel
The insulin-like growth factor system and sarcomas.
@en
The insulin-like growth factor system and sarcomas.
@nl
P2093
P2860
P356
P1476
The insulin-like growth factor system and sarcomas
@en
P2093
Bart Rikhof
Coby Meijer
Steven de Jong
Winette T A van der Graaf
P2860
P304
P356
10.1002/PATH.2499
P577
2009-03-01T00:00:00Z