The regulation of aging: does autophagy underlie longevity?
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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesAutophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSAmino acid homeostasis and chronological longevity in Saccharomyces cerevisiaeMitochondria and the autophagy-inflammation-cell death axis in organismal agingEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Trehalose Accumulation Triggers Autophagy during Plant DesiccationAberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencyTeaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approachesAUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effectsSenescence, ageing and death of the whole plant.Emerging roles of SUMO modification in arthritis.Aging and energetics' 'Top 40' future research opportunities 2010-2013.Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease.SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survivalThe biology of aging and frailty.Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegansAging and gastrointestinal neuromuscular function: insights from within and outside the gut.Autophagy and cartilage homeostasis mechanisms in joint health, aging and OAThe pleiotropic effect of physical exercise on mitochondrial dynamics in aging skeletal muscle.Autophagy impairment in a mouse model of neuropathic painSkeletal muscle mitochondria and aging: a review.The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.The autophagic lysosomal system in outflow pathway physiology and pathophysiology.Dual role of autophagy in HIV-1 replication and pathogenesisSuppression of autophagy in osteocytes mimics skeletal aging.Basic biology of skeletal aging: role of stress response pathways.The Interplay between Autophagy and Aging.Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals.Autophagy is required for zebrafish caudal fin regenerationThe regulation of autophagy - unanswered questions.Autophagy: mechanism and physiological relevance 'brewed' from yeast studies.The multiple faces of calcineurin signaling in Caenorhabditis elegans: development, behaviour and aging.Inflammatory pathways in the early steps of colorectal cancer development.Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.GSK-3α is a central regulator of age-related pathologies in mice.w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway.Aging is associated with hypermethylation of autophagy genes in macrophages.
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The regulation of aging: does autophagy underlie longevity?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 31 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The regulation of aging: does autophagy underlie longevity?
@en
The regulation of aging: does autophagy underlie longevity?
@nl
type
label
The regulation of aging: does autophagy underlie longevity?
@en
The regulation of aging: does autophagy underlie longevity?
@nl
prefLabel
The regulation of aging: does autophagy underlie longevity?
@en
The regulation of aging: does autophagy underlie longevity?
@nl
P2860
P1476
The regulation of aging: does autophagy underlie longevity?
@en
P2093
Miklós Sass
Tibor Vellai
P2860
P304
P356
10.1016/J.TCB.2009.07.007
P577
2009-08-31T00:00:00Z