Comparative analysis of editosome proteins in trypanosomatids - Wikidata - awgldk - TriplyDB

Comparative analysis of editosome proteins in trypanosomatids

Comparative analysis of editosome proteins in trypanosomatids

http://www.wikidata.org/entity/Q37371527

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Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing Functional complementation of RNA interference mutants in trypanosomes Organellar RNA editing UTP-bound and Apo Structures of a Minimal RNA Uridylyltransferase Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2 Structure and intrinsic disorder of the proteins of the Trypanosoma brucei editosome Functional and structural insights revealed by molecular dynamics simulations of an essential RNA editing ligase in Trypanosoma brucei Taking U out, with two nucleases?Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria.The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.A protein-protein interaction map of trypanosome ~20S editosomes.Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes.An RNA ligase from Deinococcus radiodurans.An essential RNase III insertion editing endonuclease in Trypanosoma brucei.OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity.The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomes Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins.Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei.Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei.Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function.KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei.Differential functions of two editosome exoUases in Trypanosoma brucei.The Architecture of Trypanosoma brucei editosomes.Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.Investigating RNA editing factors from trypanosome mitochondria.Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms.The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei.TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism.RNA-editing terminal uridylyl transferase 1: identification of functional domains by mutational analysis.Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.Kinetoplastid RNA editing involves a 3' nucleotidyl phosphatase activity.The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle.

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P2860

Comparative analysis of editosome proteins in trypanosomatids

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2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Comparative analysis of editosome proteins in trypanosomatids

@en

Comparative analysis of editosome proteins in trypanosomatids.

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type

label

Comparative analysis of editosome proteins in trypanosomatids

@en

Comparative analysis of editosome proteins in trypanosomatids.

@nl

prefLabel

Comparative analysis of editosome proteins in trypanosomatids

@en

Comparative analysis of editosome proteins in trypanosomatids.

@nl

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Nucleic Acids Research

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Comparative analysis of editosome proteins in trypanosomatids

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Elizabeth A Worthey

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I Saira Mian

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Kenneth Stuart

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Reza Salavati

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein

Homodimerization of the human U1 snRNP-specific protein C

Comparative sequence analysis of ribonucleases HII, III, II PH and D

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria

Conserved domains in DNA repair proteins and evolution of repair systems

Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4

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31

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277377378

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RNA-editing complex protein MP100, putative

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