The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
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DNA topology and transcriptionDNA structure and functionA G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamicsc-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stabilityA minimal i-motif stabilized by minor groove G:T:G:T tetradsSolution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug DesignCentromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base PairsDNA polymorphism in crystals: three stable conformations for the decadeoxynucleotide d(GCATGCATGC)G-quadruplexes in pathogens: a common route to virulence control?G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human GenomeExploring possible DNA structures in real-time polymerase kinetics using Pacific Biosciences sequencer dataCoexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level.I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stabilityMolecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expressionStructural insights into G-quadruplexes: towards new anticancer drugs.The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-elementTargeting G-quadruplexes in gene promoters: a novel anticancer strategy?A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming siteTheoretical analysis of competing conformational transitions in superhelical DNA.Making sense of G-quadruplex and i-motif functions in oncogene promoters.The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity.G-quadruplex and i-motif are mutually exclusive in ILPR double-stranded DNA.Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.Intramolecular folding in human ILPR fragment with three C-rich repeatsTargeting MYC Expression through G-Quadruplexes.How long is too long? Effects of loop size on G-quadruplex stability.The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1.Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor geneThe genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coliRegulation of tyrosine hydroxylase transcription by hnRNP K and DNA secondary structureDNA acting like RNA.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements.Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter regionDemonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1The importance of being supercoiled: how DNA mechanics regulate dynamic processesPromoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription
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The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The importance of negative sup ...... nd control of gene expression.
@en
The importance of negative sup ...... nd control of gene expression.
@nl
type
label
The importance of negative sup ...... nd control of gene expression.
@en
The importance of negative sup ...... nd control of gene expression.
@nl
prefLabel
The importance of negative sup ...... nd control of gene expression.
@en
The importance of negative sup ...... nd control of gene expression.
@nl
P2860
P356
P1476
The importance of negative sup ...... nd control of gene expression.
@en
P2093
Daekyu Sun
Laurence H Hurley
P2860
P304
P356
10.1021/JM900055S
P407
P577
2009-05-01T00:00:00Z