Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
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Proteoglycan form and function: A comprehensive nomenclature of proteoglycansCalcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cellsMITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancerAltered decorin expression of systemic sclerosis by UVA1 (340-400 nm) phototherapy: immunohistochemical analysis of 3 casesOncosuppressive functions of decorinAntiangiogenic mechanisms and factors in breast cancer treatmentDecorin: A Growth Factor Antagonist for Tumor Growth InhibitionThe biology of small leucine-rich proteoglycans in bone pathophysiologyBiological interplay between proteoglycans and their innate immune receptors in inflammationPivotal role for decorin in angiogenesisDecorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitopeDecorin is a biological ligand for the epidermal growth factor receptorKeratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumicanEmployment of the epidermal growth factor receptor in growth factor-independent signaling pathwaysDistinct secondary structures of the leucine-rich repeat proteoglycans decorin and biglycan. Glycosylation-dependent conformational stability.Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events.Gene expression profiles of pancreatic cancer and stromal desmoplasia.Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation.The Extracellular Matrix in Epithelial Ovarian Cancer - A Piece of a Puzzle.Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturationDecorin differentially modulates the activity of insulin receptor isoform A ligands.Sciatic nerve crush evokes a biphasic TGF-beta and decorin modulation in the rat spinal cord.Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancerOsteoblastogenesis and tumor growth in myeloma.CSPG is a secreted factor that stimulates neural stem cell survival possibly by enhanced EGFR signaling.Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cellsVascular accumulation of the small leucine-rich proteoglycan decorin in CADASIL.The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycansDecorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissueCooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesisRegulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injuryMicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar.Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.Quantification of collagen organization and extracellular matrix factors within the healing ligament.Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction.Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation.
P2860
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P2860
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1998
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@en
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@nl
type
label
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@en
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@nl
prefLabel
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@en
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@nl
P2093
P2860
P356
P1476
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
@en
P2093
D J McQuillan
D K Moscatello
P2860
P304
P356
10.1172/JCI846
P407
P577
1998-01-01T00:00:00Z