The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
about
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARAlternatively spliced isoforms of the human constitutive androstane receptorHighly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancerPXR variants: the impact on drug metabolism and therapeutic responsesHuman pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alphaActivation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cellsElucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).Overcoming drug resistance by regulating nuclear receptors.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammationExpression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not HepatotoxicityRegulation of drug resistance by human pregnane X receptor in breast cancer.The pregnane X receptor in tuberculosis therapeutics.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.Expression of the PXR gene in various types of cancer and drug resistanceA novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.Pregnane X Receptor and Cancer: Context-Specificity is Key.Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.Orphan nuclear receptors as targets for drug development.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Effect of pregnane X receptor expression on drug resistance in breast cancer.Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma.PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.
P2860
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P2860
The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The human orphan receptor PXR ...... l and neoplastic breast tissue
@ast
The human orphan receptor PXR ...... l and neoplastic breast tissue
@en
The human orphan receptor PXR ...... l and neoplastic breast tissue
@nl
type
label
The human orphan receptor PXR ...... l and neoplastic breast tissue
@ast
The human orphan receptor PXR ...... l and neoplastic breast tissue
@en
The human orphan receptor PXR ...... l and neoplastic breast tissue
@nl
prefLabel
The human orphan receptor PXR ...... l and neoplastic breast tissue
@ast
The human orphan receptor PXR ...... l and neoplastic breast tissue
@en
The human orphan receptor PXR ...... l and neoplastic breast tissue
@nl
P2093
P3181
P1476
The human orphan receptor PXR ...... l and neoplastic breast tissue
@en
P2093
P304
P3181
P407
P577
1999-08-01T00:00:00Z