about
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisFas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosisAbsence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestineAspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancerCrypt stem cells as the cells-of-origin of intestinal cancerGenetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoMsh-2 suppresses in vivo mutation in a gene dose and lesion dependent mannerMBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestineInducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-cateninMyc deletion rescues Apc deficiency in the small intestineBrca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cellsApoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.MBD2 deficiency does not accelerate p53 mediated lymphomagenesis.PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.DNA damage-induced apoptosis: insights from the mouse.Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestineLkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladderPoly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genesThe meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis.Cited1 deficiency suppresses intestinal tumorigenesis.Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivoMouse models with modified p53 sequences to study cancer and ageing.Apc and p53 interaction in DNA damage and genomic instability in hepatocytes.Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.The biology of mitochondrial disease.Milk composition and lactation of beta-casein-deficient mice.Wnt-cadherin connections in normal and neoplastic mammary epithelium.E-cadherin can limit the transforming properties of activating β-catenin mutations.MBD2 is required for correct spatial gene expression in the gut.New approaches for modelling cancer mechanisms in the mouse.p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alan R Clarke
@nl
Alan R Clarke
@sl
Alan R. Clarke
@en
Alan R. Clarke
@es
ألان آر. كلارك
@ar
type
label
Alan R Clarke
@nl
Alan R Clarke
@sl
Alan R. Clarke
@en
Alan R. Clarke
@es
ألان آر. كلارك
@ar
prefLabel
Alan R Clarke
@nl
Alan R Clarke
@sl
Alan R. Clarke
@en
Alan R. Clarke
@es
ألان آر. كلارك
@ar
P106
P1153
25955268800
P21
P31
P496
0000-0002-4281-426X