Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells
about
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesisA syngeneic variance library for functional annotation of human variation: application to BRCA2Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiationSilencing of BRCA2 decreases anoikis and its heterologous expression sensitizes yeast cells to acetic acid-induced programmed cell death.Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
P2860
Q25257372-971FEC50-E15C-4416-86CC-822D3D8E5779Q27347240-CC7086E3-D654-45F0-97AF-24C1FF2CCE5FQ33348194-C98D3BFF-B7DC-4536-A3F5-3BFC0373CAE7Q36602578-E3896C89-94E1-4006-B4FB-E536BE21A54CQ37389996-1E5537BA-D871-450F-81A6-657B18AEE6CBQ37618001-3A70BE0F-5ADF-4FDE-B9D1-43251E3ADEEAQ38987920-AD78D7A5-96F9-401E-AF65-64DD47670E29Q39126564-250F42F5-08D7-4E54-A144-A01C45F30899Q40007863-9AA9F841-85C6-4B26-BE31-C3D00F225366Q43779543-EEA9D85D-FE0A-40AE-AF0F-2BAF606A9F8A
P2860
Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells
description
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Mai 2005 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2005/05/26)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/05/26)
@nl
наукова стаття, опублікована в травні 2005
@uk
مقالة علمية (نشرت في 26-5-2005)
@ar
name
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@ast
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@en
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@nl
type
label
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@ast
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@en
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@nl
prefLabel
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@ast
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@en
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@nl
P2093
P2860
P356
P1433
P1476
Brca2 deficiency in the murine ...... taneous deletion of stem cells
@en
P2093
Douglas Winton
Teresa Patrick
Trevor Hay
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208533
P407
P577
2005-05-01T00:00:00Z
P5875
P6179
1011893029