IL-1 produced and released endogenously within human islets inhibits beta cell function.
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Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1Macrophage Expression of Inflammatory Genes in Response to EMCV InfectionEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesTranscriptional regulation of chemokine genes: a link to pancreatic islet inflammation?Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 DiabetesIdentifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetesPancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosisIL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditionsCytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activationAdenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejection.Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments.The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.Nardostachys jatamansi extract protects against cytokine-induced beta-cell damage and streptozotocin-induced diabetes.Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes.SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1.Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells.Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Gene therapy in diabetes.RNA interference for improving the outcome of islet transplantation.Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy.Oxidative stress and redox modulation potential in type 1 diabetes.Gene- and cell-based therapeutics for type I diabetes mellitus.Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmiaCytokine and chemokine production by human pancreatic islets upon enterovirus infectionDistinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell deathMechanisms of disease: inflammasome activation and the development of type 2 diabetes.Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function.Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway.Inflammation during obesity is not all bad: evidence from animal and human studies.Antiproinflammatory effects of iodixanol (OptiPrep)-based density gradient purification on human islet preparations.A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetesInterleukin-1 beta targeted therapy for type 2 diabetes.Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes.Amyloid and the macrophage: it's all about local production of IL-1β
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P2860
IL-1 produced and released endogenously within human islets inhibits beta cell function.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@en
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@nl
type
label
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@en
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@nl
prefLabel
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@en
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@nl
P2093
P2860
P356
P1476
IL-1 produced and released endogenously within human islets inhibits beta cell function.
@en
P2093
A L Scarim
J A Corbett
M H Marino
M R Heitmeier
P T Manning
P2860
P304
P356
10.1172/JCI844
P407
P577
1998-08-01T00:00:00Z