Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
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Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.T cell-derived interleukin (IL)-21 promotes brain injury following stroke in miceIL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation.Testing agents for prevention or reversal of type 1 diabetes in rodents.ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetesIL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodiesInterleukin-21 Drives Proliferation and Differentiation of Porcine Memory B Cells into Antibody Secreting Cells.B-cell cross-presentation of autologous antigen precipitates diabetes.Mechanistic basis of immunotherapies for type 1 diabetes mellituspSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood.Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasisInnate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cellsThe Emerging Role of Interleukin-21 in Transplantation.The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cellsPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Cytokine regulation of immune toleranceInterleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions.Inflammation and type one diabetes.Interleukin-21 in chronic inflammatory diseases.Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.Interleukin-21: a double-edged sword with therapeutic potential.IL-21 as a therapeutic target in inflammatory disorders.CD4 T cell differentiation in type 1 diabetes.Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation.Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells.Cytokines and type 1 diabetes: a numbers gameCTL-Promoting Effects of IL-21 Counteract Murine Lupus in the Parent→F1 Graft-versus-Host Disease Model.Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes.Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes.Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
P2860
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P2860
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Interleukin-21 is critically r ...... islet tissue in murine models.
@ast
Interleukin-21 is critically r ...... islet tissue in murine models.
@en
Interleukin-21 is critically r ...... islet tissue in murine models.
@nl
type
label
Interleukin-21 is critically r ...... islet tissue in murine models.
@ast
Interleukin-21 is critically r ...... islet tissue in murine models.
@en
Interleukin-21 is critically r ...... islet tissue in murine models.
@nl
prefLabel
Interleukin-21 is critically r ...... islet tissue in murine models.
@ast
Interleukin-21 is critically r ...... islet tissue in murine models.
@en
Interleukin-21 is critically r ...... islet tissue in murine models.
@nl
P2093
P2860
P50
P356
P1433
P1476
Interleukin-21 is critically r ...... islet tissue in murine models
@en
P2093
Carol M Y Lee
Helen M McGuire
Kylie E Webster
Shane Grey
Stacey Walters
P2860
P304
P356
10.2337/DB10-1157
P407
P577
2011-03-01T00:00:00Z