Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. - Wikidata - awgldk - TriplyDB

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

http://www.wikidata.org/entity/Q37384674

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Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin Leptin induces inflammation-related genes in RINm5F insulinoma cells Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum Insulin resistance in chronic kidney disease: a systematic review.An islet in distress: β cell failure in type 2 diabetes.The role of leptin in glucose homeostasis.Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.Induction of leptin resistance by activation of cAMP-Epac signaling.Mechanisms of insulin resistance in obesity Cytokines in the Progression of Pancreatic β-Cell Dysfunction Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice From PDE3B to the regulation of energy homeostasis Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling.The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone.A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away.Intracellular signalling pathways activated by leptin.Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus.Antenatal glucocorticoid exposure enhances the inhibition of adrenal steroidogenesis by leptin in a sex-specific fashion.Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.The effects of Leptin and Adiponectin on Pdx1, Foxm1, and PPARγ Transcription in Rat Islets of Langerhans.Inhibitory effects of leptin on pancreatic alpha-cell function.Growth factor control of pancreatic islet regeneration and function Osteoarthritis: genes, nature-nurture interaction and the role of leptin.Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.Leptin signaling: A key pathway in immune responses.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Effects of leptin replacement therapy on pancreatic β-cell function in patients with lipodystrophy.The mechanisms linking adiposopathy to type 2 diabetes.Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?

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P2860

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

http://www.wikidata.org/entity/Q37384674

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on September 1998

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@en

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@nl

type

label

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@en

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@nl

prefLabel

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@en

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

@nl

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Journal of Clinical Investigation

P1476

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

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P2093

A Z Zhao

http://www.w3.org/2001/XMLSchema#string

J A Beavo

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K E Bornfeldt

http://www.w3.org/2001/XMLSchema#string

P2860

Positional cloning of the mouse obese gene and its human homologue

Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons

Divergent signaling capacities of the long and short isoforms of the leptin receptor

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.

Regulation and function of cyclic nucleotides.

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869-873

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scholarly article

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10.1172/JCI3920

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5

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102

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1998-09-01T00:00:00Z

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9727054

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508951

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