Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.
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Disparate Epitopes Mediating Protective Heterologous Immunity to Unrelated Viruses Share Peptide-MHC Structural Features Recognized by Cross-Reactive T CellsAutoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction.Dual receptor T cells extend the immune repertoire for foreign antigens.The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusionModulation of TCRβ surface expression during TCR revision.Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cellsAntigen receptor allelic exclusion: an update and reappraisalAlloreactivity is limited by the endogenous peptide repertoireCutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease.Thymic selection revisited: how essential is it?GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes.CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transferBystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse modelMassive thymic deletion results in systemic autoimmunity through elimination of CD4+ CD25+ T regulatory cells.The highly alloreactive nature of dual TCR T cellsMHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic miceSingle-cell analysis of glandular T cell receptors in Sjögren's syndrome.Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.Dual receptor T cells mediate pathologic alloreactivity in patients with acute graft-versus-host diseaseGILT: Shaping the MHC Class II-Restricted Peptidome and CD4(+) T Cell-Mediated Immunity.Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection.Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.T follicular helper and T follicular regulatory cells have different TCR specificity.Designer T cells by T cell receptor replacement.Development of autoimmune exocrinopathy resembling Sjögren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells.Decreased CD4 and wide-ranging expression of other immune receptors after HIV-envelope-mediated formation of syncytia in vitro.Selection of dual Valpha T cells.The amount of self-antigen determines the effector function of murine T cells escaping negative selection.Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions.
P2860
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P2860
Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Expression of a second recepto ...... utoreactive effector function.
@en
Expression of a second recepto ...... utoreactive effector function.
@nl
type
label
Expression of a second recepto ...... utoreactive effector function.
@en
Expression of a second recepto ...... utoreactive effector function.
@nl
prefLabel
Expression of a second recepto ...... utoreactive effector function.
@en
Expression of a second recepto ...... utoreactive effector function.
@nl
P2093
P2860
P356
P1476
Expression of a second recepto ...... utoreactive effector function.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.17.9102
P407
P577
1996-08-01T00:00:00Z