Designing multiple ligands - medicinal chemistry strategies and challenges.
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Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's DiseaseSynthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychoticsSearching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan WanThe worldwide trend of using botanical drugs and strategies for developing global drugs.Potential strategies for increasing drug-discovery productivity.A theoretical entropy score as a single value to express inhibitor selectivity.Recent trends and observations in the design of high-quality screening collections.Rationally designed multitarget agents against inflammation and pain.Lost but making progress--Where will new analgesic drugs come from?Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide.Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives.Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligandsDual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activationThe behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice.Combining rimonabant and fentanyl in a single entity: preparation and pharmacological resultsDevelopment of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.Computational tools for polypharmacology and repurposing.Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action.Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.Opioid receptor targeting ligands for pain management: a review and update.Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.Multitarget ligands and theranostics: sharpening the medicinal chemistry sword against prion diseases.3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.Review structure- and dynamics-based computational design of anticancer drugs.Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.Structure-activity relationship studies for multitarget antithrombotic drugs.Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.Perspectives in Designing Multifunctional Molecules in Antipsychotic Drug Discovery.Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analoguesAnticancer Activity of Stilbene-Based Derivatives.Targeting multiple opioid receptors - improved analgesics with reduced side effects?Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan.Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models.Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.Novel phytochemical-antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR.
P2860
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Designing multiple ligands - medicinal chemistry strategies and challenges.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Designing multiple ligands - medicinal chemistry strategies and challenges.
@en
Designing multiple ligands - medicinal chemistry strategies and challenges.
@nl
type
label
Designing multiple ligands - medicinal chemistry strategies and challenges.
@en
Designing multiple ligands - medicinal chemistry strategies and challenges.
@nl
prefLabel
Designing multiple ligands - medicinal chemistry strategies and challenges.
@en
Designing multiple ligands - medicinal chemistry strategies and challenges.
@nl
P1476
Designing multiple ligands - medicinal chemistry strategies and challenges.
@en
P2093
Richard Morphy
Zoran Rankovic
P304
P356
10.2174/138161209787315594
P577
2009-01-01T00:00:00Z